HMG20B Antibody

Code CSB-PA010542GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
HMG20B
Alternative Names
BRAF25 antibody; BRAF35 antibody; BRCA2 associated factor 35 antibody; BRCA2-associated factor 35 antibody; High Mobility Group Protein 20B antibody; HM20B_HUMAN antibody; HMG box containing protein 20B antibody; HMG box-containing protein 20B antibody; HMG domain-containing protein 2 antibody; HMG domain-containing protein HMGX2 antibody; HMG20B antibody; SMARCE1-related protein antibody; SMARCE1r antibody; sox like antibody; Sox like transcriptional factor antibody; Sox-like transcriptional factor antibody; SOXL antibody; Structural DNA binding protein BRAF35 antibody; Structural DNA-binding protein BRAF35 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human HMG20B
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
Gene References into Functions
  1. Our data reveal a novel role for MID1 and for atypical ubiquitination in balancing BRAF35 presence, and likely its activity, within nuclear and cytoplasmic compartments PMID: 28760657
  2. Fresh insight into the mechanism by which the HMG20b-BRCA2 complex controls mitotic cell division, and implicate heterozygous HMG20b mutations affecting cytokinesis regulation in the genesis of human cancers. PMID: 25486196
  3. HMG20B/BRAF35 forms heterodimers with HMG20A/iBRAF. Heterodimerization impairs HMG20B/BRAF35 sumoylation and interaction with the LSD1-CoREST complex. PMID: 22570500
  4. a novel function for HMG20b in cytokinesis is regulated by its interaction with the BRC repeats of BRCA2 PMID: 21399666
  5. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35 PMID: 20530487
  6. molecular cloning, nucleotide and amino acid sequencing PMID: 11997092
  7. complex containing histone deacetylase complex containing histone deacetylase mediates repression of neuronal-specific genes. PMID: 12032298
  8. molecular Cloning of BRAF25, an alternatively spliced protein of BRAF35 PMID: 12083779
  9. Results demonstrating association of BRAF35 with KIF4 through the interaction of their respective alpha-helical coiled-coil domains is unique so far in mammals. PMID: 12809554
  10. we have examined Sox gene expression in 60 human primary gliomas. Transcripts from each of the six group E and group D genes were expressed in gliomas of various types and malignancy grades PMID: 17961134

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Subcellular Location
Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.
Tissue Specificity
Ubiquitously expressed in adult tissues.
Database Links

HGNC: 5002

OMIM: 605535

KEGG: hsa:10362

STRING: 9606.ENSP00000328269

UniGene: Hs.406534

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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