HMG20B Antibody

Code CSB-PA001040
Size US$100
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  • Western Blot analysis of AD293 cells using BRAF35 Polyclonal Antibody
  • Western Blot analysis of HELA 293T cells using BRAF35 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
HMG20B
Alternative Names
BRAF25 antibody; BRAF35 antibody; BRCA2 associated factor 35 antibody; BRCA2-associated factor 35 antibody; High Mobility Group Protein 20B antibody; HM20B_HUMAN antibody; HMG box containing protein 20B antibody; HMG box-containing protein 20B antibody; HMG domain-containing protein 2 antibody; HMG domain-containing protein HMGX2 antibody; HMG20B antibody; SMARCE1-related protein antibody; SMARCE1r antibody; sox like antibody; Sox like transcriptional factor antibody; Sox-like transcriptional factor antibody; SOXL antibody; Structural DNA binding protein BRAF35 antibody; Structural DNA-binding protein BRAF35 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the N-terminal region of Human BRAF35.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
Gene References into Functions
  1. Our data reveal a novel role for MID1 and for atypical ubiquitination in balancing BRAF35 presence, and likely its activity, within nuclear and cytoplasmic compartments PMID: 28760657
  2. Fresh insight into the mechanism by which the HMG20b-BRCA2 complex controls mitotic cell division, and implicate heterozygous HMG20b mutations affecting cytokinesis regulation in the genesis of human cancers. PMID: 25486196
  3. HMG20B/BRAF35 forms heterodimers with HMG20A/iBRAF. Heterodimerization impairs HMG20B/BRAF35 sumoylation and interaction with the LSD1-CoREST complex. PMID: 22570500
  4. a novel function for HMG20b in cytokinesis is regulated by its interaction with the BRC repeats of BRCA2 PMID: 21399666
  5. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35 PMID: 20530487
  6. molecular cloning, nucleotide and amino acid sequencing PMID: 11997092
  7. complex containing histone deacetylase complex containing histone deacetylase mediates repression of neuronal-specific genes. PMID: 12032298
  8. molecular Cloning of BRAF25, an alternatively spliced protein of BRAF35 PMID: 12083779
  9. Results demonstrating association of BRAF35 with KIF4 through the interaction of their respective alpha-helical coiled-coil domains is unique so far in mammals. PMID: 12809554
  10. we have examined Sox gene expression in 60 human primary gliomas. Transcripts from each of the six group E and group D genes were expressed in gliomas of various types and malignancy grades PMID: 17961134

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Subcellular Location
Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.
Tissue Specificity
Ubiquitously expressed in adult tissues.
Database Links

HGNC: 5002

OMIM: 605535

KEGG: hsa:10362

STRING: 9606.ENSP00000328269

UniGene: Hs.406534

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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