HOXA2 Antibody

Code CSB-PA010652LA01HU
Size US$166
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Image
  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA010652LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA010652LA01HU at dilution of 1:100

  • Western Blot
    Positive WB detected in: Jurkat whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Mouse stomach tissue
    All lanes: Hoxa2 antibody at 2μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 42 kDa
    Observed band size: 42 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HOXA2 Polyclonal antibody
Uniprot No.
Target Names
HOXA2
Alternative Names
AI324701 antibody; homeo box A2 antibody; homeobox A2 antibody; Homeobox protein Hox-1K antibody; Homeobox protein Hox-A2 antibody; Hox-1.11 antibody; HOX1.11 antibody; HOX1K antibody; Hoxa-2 antibody; Hoxa11 antibody; HOXA2 antibody; HXA2_HUMAN antibody; MGC151482 antibody; MGC151484 antibody; RATHOX111A antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Homeobox protein Hox-A2 protein (26-124AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The HOXA2 Antibody (Product code: CSB-PA010652LA01HU) is Non-conjugated. For HOXA2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA010652LB01HU HOXA2 Antibody, HRP conjugated ELISA
FITC CSB-PA010652LC01HU HOXA2 Antibody, FITC conjugated
Biotin CSB-PA010652LD01HU HOXA2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:2000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description
HOXA2 polyclonal antibody CSB-PA010652LA01HU was produced in rabbit immunized by using the Recombinant Human Homeobox protein Hox-A2 protein (26-124AA) as the immunogen. The target protein HOXA2 is sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Diseases associated with HOXA2 include Microtia, Hearing Impairment, and Cleft Palate and Microtia.
This Rabbit anti-Homo sapiens (Human) HOXA2 Polyclonal antibody was tested in the ELISA, WB and IHC. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It reacts with the HOXA2 proteins of human or mouse-origin and may be used to detect the endogenous levels of HOXA2 protein.

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Target Background

Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Gene References into Functions
  1. Performed mutational analysis of TCOF1, GSC, and HOXA2 to determine the mutational features of the 3 genes in Chinese patients with Treacher Collins syndrome. PMID: 27526242
  2. The role of HOXA2 gene in dominant isolated microtia and the dysmorphogenetic effect of this gene on ear development PMID: 27503514
  3. 5 genomic variants in GSC, HOXA2 and PRKRA were identified through mutational analysis in Chinese patients with microtia. PMID: 28109504
  4. The Hoxa2-mediated decay of RCHY1 involves both the 19S and 20S proteasome complexes PMID: 26496426
  5. HOXA2 acts as a suppressor or TBP-antagonist to inhibit MMP-9 expression; while methylation-mediated inactivation of HOXA2 in NPC derepresses MMP-9 production and increases invasion of NPC cells. PMID: 24243817
  6. we have identified a nonsense mutation (Q235*) in HOXA2 that segregates with bilateral nonsyndromic microtia and hearing loss through three generations of a family in an autosomal dominant pattern. PMID: 23775976
  7. Lack of mutations in the coding region of HOXA2 among the sporadic microtia patients. PMID: 20542577
  8. A missense mutation in the HOXA2 in a consanguineous iranian family with bilateral microtia was reported. PMID: 18394579

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Involvement in disease
Microtia, hearing impairment, and cleft palate (MHICP); Microtia with or without hearing impairment (MCRT)
Subcellular Location
Nucleus.
Protein Families
Antp homeobox family, Proboscipedia subfamily
Database Links

HGNC: 5103

OMIM: 604685

KEGG: hsa:3199

STRING: 9606.ENSP00000222718

UniGene: Hs.445239

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