HYAL3 Antibody

Datasheet

Code	CSB-PA010920ESR2HU
Size	US$166
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Image	Western blot All lanes: HYAL3 antibody at 4μg/ml + Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 47, 44, 19, 16 kDa Observed band size: 47 kDa Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010920ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA010920ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) HYAL3 Polyclonal antibody

Uniprot No.

O43820

Target Names

HYAL3

Alternative Names

Hyal-3 antibody; HYAL3 antibody; HYAL3_HUMAN antibody; Hyaluronidase 3 antibody; Hyaluronidase-3 antibody; Hyaluronoglucosaminidase 3 antibody; Hyaluronoglucosaminidase-3 antibody; LUCA-3 antibody; LUCA14 antibody; LUCA3 antibody; Lung carcinoma protein 3 antibody; Minna14 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Hyaluronidase-3 protein (198-417AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.

Gene References into Functions

the relative expression of hyalurosome (CD44, HAS3, HB-EGF) genes was found to be reduced in patients prior to topical treatment and to be notably increased following treatment. PMID: 25138066
mutations of the HYAL3 gene are rare in Chinese lung squamous cell carcinoma patients and might contribute to lymph node metastasis PMID: 23549009
polymorphisms in HYAL3 are potentially involved in glaucomatous neurodegeneration. PMID: 22960332
Nodular basal cell carcinoma is associated with increased levels of hyaluronic acid concomitant with upregulation of gene expression of HAS3, HYAL3 and RHAMM, when compared with normal adjacent skin. PMID: 20849445
Overexpression of HYAL3 is associated with colorectal cancer. PMID: 20849597
Hyal3 null sperm showed delayed cumulus penetration and reduced acrosomal exocytosis. PMID: 20586096
Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. PMID: 11929860
Alternative mRNA splicing controls cellular expression of enzymatically active hyaluronidase. PMID: 12084718
Down-regulation of HYAL3 is associated with small cell lung cancer and glioma PMID: 12684632

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Subcellular Location

Secreted. Cell membrane. Cytoplasmic vesicle, secretory vesicle, acrosome. Endoplasmic reticulum. Early endosome.

Protein Families

Glycosyl hydrolase 56 family

Tissue Specificity

Expressed in sperm. Highly expressed in epidermis of the skin, where it is expressed intracellularily in the deep horny layer (at protein level). Bone marrow, testis and kidney.

Database Links

HGNC: 5322

OMIM: 604038

KEGG: hsa:8372

STRING: 9606.ENSP00000337425

UniGene: Hs.129910

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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