Histone H3.1 (Ab-10) Antibody

Datasheet
Code CSB-PA585914
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P68431
Image
  • Western blot analysis of extracts from 293 cells using Histone H3.1(Ab-10) Antibody.
  • Immunofluorescence staining of methanol-fixed Hela cells using Histone H3.1(Ab-10) Antibody.
Immunogen Peptide sequence around aa.8~12 (R-K-S-T-G) derived from Human Histone H3.1.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous level of total Histone H3.1 protein.
Tested Applications ELISA,WB,IF;WB:1:500-1:1000,IF:1:100-1:200
Relevance Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Workman, J.L. and Kingston, R.E. (1998) Annu Rev Biochem 67, 545-79.
Hansen, J.C. et al. (1998) Biochemistry 37, 17637-41.
Strahl, B.D. and Allis, C.D. (2000) Nature 403, 41-5.
Cheung, P. et al. (2000) Cell 103, 263-71.
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality Polyclonal
Alias H3/a; H3/c; H3/d; H3/f; H3/h
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Target Names HIST1H3A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Involvement in disease Glioma (GLM)
Subcellular Location Nucleus, Chromosome
Protein Families Histone H3 family
Database Links

HGNC: 4766

OMIM: 137800

KEGG: hsa:8350

STRING: 9606.ENSP00000444823

UniGene: Hs.132854

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