IARS2 Antibody

Code CSB-PA002995
Size US$100
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  • Western Blot analysis of COS7 cells using IARS2 Polyclonal Antibody
  • Western Blot analysis of HELA A549 cells using IARS2 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
IARS2
Alternative Names
2010002H18Rik antibody; C79125 antibody; EC 6.1.1.5 antibody; FLJ10326 antibody; Iars2 antibody; IleRS antibody; isoleucine tRNA ligase 2, mitochondrial antibody; isoleucine tRNA ligase, mitochondrial antibody; isoleucine tRNA synthetase 2, mitochondrial antibody; Isoleucine--tRNA ligase antibody; isoleucine-tRNA synthetase 2 antibody; isoleucyl tRNA synthetase 2, mitochondrial antibody; Isoleucyl-tRNA synthetase antibody; MGC63429 antibody; mitochondrial antibody; mitochondrial isoleucine tRNA synthetase antibody; rCG_20084 antibody; RGD1311857 antibody; SYIM_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Monkey
Immunogen
Synthesized peptide derived from the N-terminal region of Human IARS2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. IARS2 silencing induced NSCLC cells growth inhibition, cell cycle arrest and promoted cell apoptosis PMID: 26639235
  2. Patients with this very rare mutation present with a myriad of ocular findings, including infantile cataract, neurotrophic keratitis, corneal opacification, and orbital myopathy. PMID: 27078007
  3. The expression of IARS2 gene is different in human colon cancer and surrounding tissues. IARS2 gene is probably a cancer-promoting gene PMID: 26722399
  4. This study is the first report of clinical findings associated with IARS2 mutations. PMID: 25130867
Involvement in disease
Cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia (CAGSSS)
Subcellular Location
Mitochondrion matrix.
Protein Families
Class-I aminoacyl-tRNA synthetase family
Database Links

HGNC: 29685

OMIM: 612801

KEGG: hsa:55699

STRING: 9606.ENSP00000303279

UniGene: Hs.262823

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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