IK Antibody

Code CSB-PA003006
Size US$100
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  • Western Blot analysis of HeLa cells using IK Polyclonal Antibody
  • Western blot analysis of HELA KB SH-SY5Y 293T 3T3 lysis using IK antibody.
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Product Details

Uniprot No.
Target Names
Alternative Names
chondrosarcoma associated protein 2 antibody; CSA2 antibody; Cytokine IK antibody; IK antibody; IK cytokine down regulator of HLA II antibody; IK factor antibody; IK Gene antibody; prer protein antibody; Protein Red antibody; Protein RER antibody; RD element antibody; RED protein antibody; RED_HUMAN antibody; RER antibody
Raised in
Species Reactivity
Synthesized peptide derived from the C-terminal region of Human IK.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1.; (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.
Gene References into Functions
  1. IK inhibits Aurora B activation through recruiting PP2A into IK and Aurora B complex. PMID: 26906715
  2. Data suggest an indirect radiosensitivity of hIK channels to low-dose photon irradiation with an impact on cell differentiation. PMID: 25277267
  3. Data suggest that two human spliceosomal factors, RED and SMU1, are recruited to control expression and alternative splicing of viral exportins via PB2 (polymerase PB2) of influenza A virus (H3N2) and are required for efficient viral multiplication. PMID: 24945353
  4. IK is an essential protein for achieving correct mitotic progress through the regulation of mitotic kinases and phosphatases PMID: 24996188
  5. RED is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. PMID: 22351768
  6. IK gene expression is decreased in follicular variant of papillary thyroid carcinoma. PMID: 21509594
  7. At least three genes, orthologous to loci in this LD block, HBEGF, IK, and SRA1, result independently in a phenotype of myocardial contractile dysfunction when their expression is reduced with morpholino antisense reagents. PMID: 19064678

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Subcellular Location
Nucleus. Nucleus, nucleoplasm. Chromosome. Cytoplasm, cytoskeleton, spindle pole.
Protein Families
RED family
Tissue Specificity
Database Links

HGNC: 5958

OMIM: 600549

KEGG: hsa:3550

STRING: 9606.ENSP00000396301

UniGene: Hs.421245

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