IK Antibody

Datasheet

Code	CSB-PA003006
Size	US$119
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Image	Western Blot analysis of HeLa cells using IK Polyclonal Antibody Western blot analysis of HELA KB SH-SY5Y 293T 3T3 lysis using IK antibody.
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Product Details
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Target Background

Product Details

Uniprot No.

Q13123

Target Names

Alternative Names

chondrosarcoma associated protein 2 antibody; CSA2 antibody; Cytokine IK antibody; IK antibody; IK cytokine down regulator of HLA II antibody; IK factor antibody; IK Gene antibody; prer protein antibody; Protein Red antibody; Protein RER antibody; RD element antibody; RED protein antibody; RED_HUMAN antibody; RER antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the C-terminal region of Human IK.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:20000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1.; (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.

Gene References into Functions

IK inhibits Aurora B activation through recruiting PP2A into IK and Aurora B complex. PMID: 26906715
Data suggest an indirect radiosensitivity of hIK channels to low-dose photon irradiation with an impact on cell differentiation. PMID: 25277267
Data suggest that two human spliceosomal factors, RED and SMU1, are recruited to control expression and alternative splicing of viral exportins via PB2 (polymerase PB2) of influenza A virus (H3N2) and are required for efficient viral multiplication. PMID: 24945353
IK is an essential protein for achieving correct mitotic progress through the regulation of mitotic kinases and phosphatases PMID: 24996188
RED is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. PMID: 22351768
IK gene expression is decreased in follicular variant of papillary thyroid carcinoma. PMID: 21509594
At least three genes, orthologous to loci in this LD block, HBEGF, IK, and SRA1, result independently in a phenotype of myocardial contractile dysfunction when their expression is reduced with morpholino antisense reagents. PMID: 19064678

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Subcellular Location

Nucleus. Nucleus, nucleoplasm. Chromosome. Cytoplasm, cytoskeleton, spindle pole.

Protein Families

RED family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 5958

OMIM: 600549

KEGG: hsa:3550

STRING: 9606.ENSP00000396301

UniGene: Hs.421245

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