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IL17B Antibody

Datasheet
Code CSB-PA648539
Size US$167
Image
  • Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200
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Product Details

Uniprot No. Q9UHF5
Target Names IL17B
Alternative Names Cytokine like protein Zcyto7 antibody; Cytokine Zcyto7 antibody; IL 17B antibody; IL 20 antibody; IL-17B antibody; IL-20 antibody; IL17B antibody; IL17B_HUMAN antibody; IL20 antibody; Interleukin 17 beta antibody; Interleukin 17B antibody; Interleukin 20 antibody; Interleukin-17B antibody; Interleukin-20 antibody; MGC138900 antibody; MGC138901 antibody; Neuronal interleukin 17 related factor antibody; Neuronal interleukin-17-related factor antibody; NIRF antibody; ZCYTO7 antibody
Raised in Rabbit
Species Reactivity Human,Rat
Immunogen Synthetic peptide from Human protein at AA range: 1-50
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Purification Method The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form Liquid
Tested Applications IHC,ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:50-300
ELISA 1:10000-20000
Protocols Immunohistochemistry (IHC) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
Gene References into Functions
  1. The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells. PMID: 27146881
  2. Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells. PMID: 28145881
  3. Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family PMID: 27703147
  4. This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW} PMID: 28160754
  5. Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy. PMID: 26285835
  6. IL-17B-IL-17RB signaling promotes pancreatic cancer malignancy. PMID: 25732306
  7. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells. PMID: 23851503
  8. IL-17B can enhance the effects of TNF-alpha on the production of cytokines and chemokines that control immune cell trafficking and neutrophil homeostasis in the inflamed tissues. PMID: 24056520
  9. IL-17A, IL-17B, IL-17F and IL-23 in systemic lupus erythematosus patients were examined and the correlation between levels of the investigated cytokines and VEGF, PIGF, as well as number of endothelial cells, was investigated. PMID: 23661335
  10. expression and functional study of IL-17B PMID: 22394632
  11. IL-17 may play an important role in the occurrence of nasal polyps by overexpression. PMID: 16805377

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Subcellular Location Secreted
Protein Families IL-17 family
Tissue Specificity Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
Database Links

HGNC: 5982

OMIM: 604627

KEGG: hsa:27190

STRING: 9606.ENSP00000261796

UniGene: Hs.156979
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Related pathways
IL-17 signaling pathway

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