ILKAP Antibody

Code CSB-PA011686HA01HU
Size US$166
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  • Western blot
    All lanes: ILKAP antibody at 2µg/ml
    Lane 1: Rat kidney tissue
    Lane 2: U251 whole cell lysate
    Lane 3: Mouse stomach tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 43 kDa
    Observed band size: 43 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ILKAP Polyclonal antibody
Uniprot No.
Target Names
ILKAP
Alternative Names
DKFZp434J2031 antibody; FLJ10181 antibody; ILKAP antibody; ILKAP_HUMAN antibody; ILKAP2 antibody; ILKAP3 antibody; Integrin linked kinase associated phosphatase antibody; Integrin linked kinase associated serine/threonine phosphatase 2C antibody; Integrin linked kinase associated serine/threonine phosphatase antibody; Integrin-linked kinase-associated serine/threonine phosphatase 2C antibody; MGC4846 antibody; PP2C DELTA antibody; Protein phosphatase 2c delta isozyme antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human Integrin-linked kinase-associated serine/threonine phosphatase 2C protein (1-392AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ILKAP Antibody (Product code: CSB-PA011686HA01HU) is Non-conjugated. For ILKAP Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA011686HB01HU ILKAP Antibody, HRP conjugated ELISA
FITC CSB-PA011686HC01HU ILKAP Antibody, FITC conjugated
Biotin CSB-PA011686HD01HU ILKAP Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
Gene References into Functions
  1. ILKAP physically interacted with HIF-1A and induced its dephosphorylation. Both the HIF-1A-p53 interaction and apoptosis relied on ILKAP. PMID: 29742494
  2. our data suggest an essential role of PINCH1, ILK and ILKAP for the radioresistance of p53-wildtype glioblastoma multiforme cells PMID: 26460618
  3. The expression of ILKAP was considerably lower in eutopic and ectopic endometrial samples from women with endometriosis than in control endometrium. Expression varied depending on the phase of the menstrual cycle. PMID: 25872452
  4. Data show involvement of ANXA5 and ILKAP in susceptibility to malignant melanoma PMID: 24743186
  5. ILKAP is a nuclear protein that regulates cell survival and apoptosis through the regulation of RSK2 signaling. PMID: 23329845
  6. these results suggested that palladin played a specific role in modulating the subcellular localization of the cytoplasmic ILKAP and promoting the ILKAP-induced apoptosis. PMID: 21782789

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Subcellular Location
Cytoplasm.
Protein Families
PP2C family
Tissue Specificity
Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
Database Links

HGNC: 15566

KEGG: hsa:80895

STRING: 9606.ENSP00000254654

UniGene: Hs.92033

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