IMPA1 Antibody

Datasheet

Code	CSB-PA011694GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

P29218

Target Names

IMPA1

Alternative Names

IMP 1 antibody; IMP antibody; IMPA 1 antibody; IMPA antibody; IMPA1 antibody; IMPA1_HUMAN antibody; IMPase 1 antibody; IMPase antibody; Inositol 1(or 4) monophosphatase antibody; Inositol monophosphatase 1 antibody; Inositol monophosphatase antibody; Inositol(myo) 1(or 4) monophosphatase 1 antibody; Inositol-1(or 4)-monophosphatase 1 antibody; Lithium sensitive myo inositol monophosphatase A1 antibody; Lithium-sensitive myo-inositol monophosphatase A1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human IMPA1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.

Gene References into Functions

Multibody magnesium cofactor and myo-inositol substrate molecular recognition in the myo-inositol monophosphatase enzyme have been described. PMID: 27440438
The identification of a novel homozygous duplication of 5 bp in IMPA1, in a large consanguineous family with nine individuals with severe intellectual disability and disruptive behavior. PMID: 26416544
Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A PMID: 23027737
The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 transgenic mice might represent some aspect relevant to the inositol depletion hypothesis. PMID: 20153384
No association between polymorphisms and bipolar disorder PMID: 14699425
IMPA2 has a separate function in vivo from that of IMPA1 PMID: 17068342

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Involvement in disease

Mental retardation, autosomal recessive 59 (MRT59)

Subcellular Location

Cytoplasm.

Protein Families

Inositol monophosphatase superfamily

Database Links

HGNC: 6050

OMIM: 602064

KEGG: hsa:3612

STRING: 9606.ENSP00000408526

UniGene: Hs.656694

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Phosphatidylinositol signaling system

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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