ING5 Antibody

1. our results demonstrate, for the first time that overexpression of ING5 in osteosarcoma cells induces apoptosis PMID: 29528777
2. ING5 promotes brain tumor initiating cells stemness by maintaining intracellular calcium levels and activating the follicle stimulating hormone pathway. PMID: 28925404
3. Nucleocytoplasmic translocation of ING5 protein occurs in breast cancer, and the high expression of nuclear ING5 is inversely related to some poor clinicopathological behaviors of breast cancer. PMID: 29595458
4. Overexpression of ING5 inhibited cell proliferation, neoplasm invasion and epithelial-mesenchymal transition of thyroid cancer cells. PMID: 29272787
5. We revealed that miR-24 had the opposite effects to those of ING5 on breast cancer cells and could accelerate xenografted tumor growth in vivo. Our findings uncover the tumor-suppressive role of ING5 and the regulatory pathway of ING5 in breast cancer and may provide insights into the molecular mechanisms of breast carcinogenesis PMID: 28490335
6. ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-kappaB/MMP-9 signaling pathway. PMID: 29326045
7. Data suggest that inhibitor of growth protein 5 (ING5) downregulation might involved in carcinogenesis, growth, and invasion of lung cancer and could be considered as a promising marker to gauge the aggressiveness of lung cancer. PMID: 27409347
8. miR-1307 could promote ovarian cancer chemoresistance by targeting the ING5 expression and miR-1307 might serve as a therapeutic target for ovarian cancer. PMID: 28086946
9. miR-331-3p is upregulated by HBV and promotes proliferation of hepatocellular carcinoma cells though repression of ING5 expression. PMID: 26497554
10. Suggest that ING5 expression might be a good marker for gastric carcinogenesis and its subsequent progression by inhibiting proliferation, growth, migration, invasion and metastasis. PMID: 25980581
11. Loss of ING5 expression is associated with lung cancer. PMID: 25938545
12. Identified ING5 as a novel CDK2 substrate. ING5 is phosphorylated at a single site, threonine 152, by cyclin E/CDK2 and cyclin A/CDK2. This site is also phosphorylated in cells in a cell cycle dependent manner, consistent with it being a CDK2 substrate. PMID: 25860957
13. Results showed that ING5 gene expression is inhibited by miR-193a-3p and is instrumental in miR-193a-3p's role in activating BCa chemoresistance. PMID: 25991669
14. Data indicate that ING5 associates with Tip60 (KAT5) to form a complex with p53. PMID: 23576563
15. ING5 down-regulation promotes bone mesenchymal stem cell proliferation. PMID: 22384930
16. Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1. PMID: 21750715
17. EBNA3C negatively regulate p53-mediated functions by interacting with ING4 and ING5. PMID: 21177815
18. Aberrant inhibitor of growth 5 expression may contribute to pathogenesis, growth, and invasion of colorectal carcinomas. PMID: 21193223
19. ). Survival analysis indicated that nuclear ING5 was closely linked to favorable prognosis of carcinoma patients (P < .05), albeit not independent. PMID: 21062663
20. Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion. PMID: 20131318
21. ING5 may function as a tumor suppressor gene or oncogene tightly linked with p53 status, and may play an important role in the prognosis of head and neck squamous cell carcinoma (HNSCC) patients. PMID: 20182888
22. Tumor-specific mutation and down-regulation of ING5 mRNA suggested it as a tumor suppressor gene in oral squamous cell carcinoma PMID: 20131318
23. p29ING4 and p28ING5 may be significant modulators of p53 function. PMID: 12750254
24. the PHD domain of ING5 has the characteristic tertiary fold of a zinc finger. PMID: 18623064

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HGNC: 19421

OMIM: 608525

KEGG: hsa:84289

STRING: 9606.ENSP00000322142

UniGene: Hs.529172