INO80 Antibody, Biotin conjugated

Code CSB-PA892466LD01HU
Size US$299
Uniprot No. Q9ULG1
Protocols ELISA Protocol
Immunogen Recombinant Human Chromatin-remodeling ATPase INO80 protein (1365-1495AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820).
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Chromatin-remodeling ATPase INO80 (hINO80) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A), INO80, INO80A, INOC1, KIAA1259
Immunogen Species Human
Research Area Epigenetics and Nuclear Signaling
Target Names INO80
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed
Subcellular Location Nucleus
Protein Families SNF2/RAD54 helicase family
Tissue Specificity According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.
Database Links

HGNC: 26956

OMIM: 610169

KEGG: hsa:54617

STRING: 9606.ENSP00000355205

UniGene: Hs.292949

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