Recombinant Human DNA helicase INO80 (INO80), partial

1. human INO80 chromatin remodeling complex is more compositionally heterogenous at its genomic targets than anticipated. PMID: 29432129
2. structure of the human INO80 chromatin remodeller with a bound nucleosome, which reveals that INO80 interacts with nucleosomes in a previously undescribed manner PMID: 29643506
3. INO80-silencing MSC cultured in osteogenic condition expressed lower mRNA levels of osteoblast-specific genes, including Runx2, Osx, Col1alpha1 and OCN. INO80 can interact with Wdr5 in MSC and positively regulates the canonical Wnt signaling transduction. PMID: 27804957
4. Instead nucleosome sliding requires cooperativity between two INO80 complexes that monitor DNA length simultaneously on either side of the nucleosome during sliding. The C-terminal domain of the human Ino80 subunit (Ino80CTD) binds cooperatively to DNA and dimerisation of these domains provides crosstalk between complexes. PMID: 28585918
5. Ino80 was upregulated in cervical cancer and promoted cell proliferation and tumorigenesis by binding to the Nanog transcription start site and enhancing its expression. PMID: 27750218
6. By demonstrating a key role for SUMOylation in regulating the INO80 chromatin remodeling complex, this work illustrates the power of bioinformatics analysis of large data sets in predicting novel biological phenomena. PMID: 28254775
7. Our work defines SETD2 as a tumor suppressor gene in Hepatosplenic T-cell lymphoma (HSTL)and implicates genes including INO80 and PIK3CD in the disease PMID: 28122867
8. our study defines a critical role of INO80 in promoting oncogenic transcription and NSCLC tumorigenesis, and reveals a potential treatment strategy for inhibiting the cancer transcription network by targeting the INO80 chromatin remodeling complex. PMID: 27641337
9. Interactions of the chromatin remodeling protein INO80 with DNA, and the role of YY1 in this process have been described. PMID: 27428271
10. The inositol hexaphosphate binding site is located within the C-terminal region of the Ino80 subunit. PMID: 27257055
11. the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80/YY1 complex. PMID: 27535137
12. The expression of Ino80, the SWI/SNF ATPase, is elevated in melanoma cells and patient melanomas compared with normal melanocytes and benign nevi. PMID: 27340176
13. Overexpression of miRNA-148a and knockdown of INO80 acted synergistically to decrease the expression of stem cell marker genes as well as to attenuate stem cell-specific properties including the ability to form tumors. PMID: 27779717
14. INO80 complex negatively regulates p21 expression in a p53-mediated mechanism and is implicated in cell cycle phase G2/M arrest and abnormal chromosome stability. PMID: 26340092
15. INO80 is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells PMID: 25283999
16. Mutations in INO80D is associated with translocation renal cell carcinoma. PMID: 24899691
17. The data indicate that under conditions of replication stress INO80 protects stalled forks from collapsing and allows their subsequent restart. PMID: 25016522
18. human Inositol auxotrophy 80 (Ino80) SNF2 ATPase is subject to regulation at multiple levels in the INO80 chromatin-remodeling complex. PMID: 24297934
19. These results suggest that the human INO80 complex, like the yeast complex, was involved in the DNA damage tolerance pathway and that phosphorylation of human INO80 was involved in the DNA damage tolerance pathway. PMID: 22166198
20. These results suggest that hIno80 can play a direct role in the spindle assembly independent of its chromatin remodeling activity. PMID: 22133677
21. Ino80 mediates double-strand break repair through its role in DNA end strand resection PMID: 21947284
22. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. PMID: 21303910
23. These results suggest that hINO80 assists double-strand break repair by positively regulating the expression of the Rad54B and XRCC3 genes. PMID: 20687897
24. hINO80 associates with spindle microtubule during mitosis, and its deficiency leads to defective microtubule assembly and abnormal chromosome segregation. PMID: 20237820
25. report the cloning, expression, and functional activity of the domains from hINO80 gene both in terms of the DNA dependent ATPase as well as DNA binding activity PMID: 16298340
26. Methods for purification and assay of the INO80 chromatin remodeling complexes are described. PMID: 17101442
27. Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters PMID: 17721549
28. Ino80 has a crucial role in stabilizing a stalled replisome to ensure proper restart of DNA replication PMID: 18376411
29. INO80 is an important new player in DNA replication to help safeguard the integrity of the genome PMID: 18388905
30. In the nucleus Uch37 is also associated with the human Ino80 chromatin-remodeling complex (hINO80). PMID: 18922472
31. Identifies INOC1 gene product as a SNF2-like helicase associated with human INO80 chromatin remodeling complex (hINO80). hINO80 includes orthologs of 8 subunits of the yeast INO80 complex, as well as additional, metazoan-specific proteins. PMID: 16230350

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HGNC: 26956

OMIM: 610169

KEGG: hsa:54617

STRING: 9606.ENSP00000355205

UniGene: Hs.292949