INPP5F Antibody, FITC conjugated

Code CSB-PA896692NC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) INPP5F Polyclonal antibody
Uniprot No.
Target Names
INPP5F
Alternative Names
INPP5F antibody; KIAA0966 antibody; SAC2 antibody; MSTP007 antibody; MSTP047 antibody; Phosphatidylinositide phosphatase SAC2 antibody; EC 3.1.3.25 antibody; Inositol polyphosphate 5-phosphatase F antibody; Sac domain-containing inositol phosphatase 2 antibody; Sac domain-containing phosphoinositide 4-phosphatase 2 antibody; hSAC2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence from Human Phosphatidylinositide phosphatase SAC2 protein (187-204AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress. May play a role as negative regulator of axon regeneration after central nervous system injuries.
Gene References into Functions
  1. we identified inositol polyphosphate-5-phosphatase F (INPP5F) as a prognostic factor for progression-free survival in Chronic lymphocytic leukemia PMID: 26430724
  2. These findings suggest that INPP5F is a potential tumor suppressor in gliomas via inhibition of STAT3 pathway, and that deregulation of INPP5F may lead to contribution to gliomagenesis. PMID: 25476455
  3. Sac2 colocalizes with early endosomal markers and is recruited to transferrin-containing vesicles during endocytic recycling. PMID: 25869669
  4. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. PMID: 19875726
Subcellular Location
Membrane, clathrin-coated pit. Early endosome. Recycling endosome.
Tissue Specificity
Ubiquitous. Highly expressed in brain.
Database Links

HGNC: 17054

OMIM: 609389

KEGG: hsa:22876

STRING: 9606.ENSP00000354519

UniGene: Hs.369755

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