IRF9 Antibody, Biotin conjugated

Code CSB-PA011824LD01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) IRF9 Polyclonal antibody
Uniprot No. Q00978
Target Names IRF9
Alternative Names IFN alpha responsive transcription factor subunit antibody; IFN-alpha-responsive transcription factor subunit antibody; Interferon regulatory factor 9 antibody; interferon stimulated transcription factor 3 antibody; Interferon-stimulated gene factor 3 gamma antibody; interferon-stimulated transcription factor 3, gamma 48kDa antibody; IRF 9 antibody; IRF-9 antibody; Irf9 antibody; IRF9_HUMAN antibody; ISGF 3 gamma antibody; ISGF-3 gamma antibody; ISGF3 antibody; ISGF3 p48 subunit antibody; ISGF3G antibody; OTTHUMP00000164692 antibody; OTTHUMP00000164693 antibody; p48 antibody; Transcriptional regulator ISGF3 subunit gamma antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Interferon regulatory factor 9 protein (44-180AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Gene References into Functions
  1. Priming cells with IFNbeta synergistically enhances IL6 induction in response to treatments that activate NF-kappaB, in a process that depends upon the recruitment of STAT2, IRF9. PMID: 29581268
  2. Surface features in the interacting domains of IRF9 and STAT2 have diverged to enable specific interaction between these family members and to enable the antiviral response. PMID: 29317535
  3. Recent studies have revealed a unique role for IRF9 as a conductor of the cellular responses to IFN-Is. Intriguingly, novel roles for IRF9 outside of the antiviral response are also being identified. PMID: 26987614
  4. these findings identify miR-302d as a key regulator of type I IFN driven gene expression via its ability to target IRF9 and regulate ISG expression, underscoring the importance of non-coding RNA in regulating the IFN pathway in SLE. PMID: 28318807
  5. Decreased IRF9 expression was accompanied by increased replication of hepatitis C virus and hepatitis E virus. PMID: 28442624
  6. PKV VP3 associated with STAT2 and IRF9, and interfered with the formation of the STAT2-IRF9 and STAT2-STAT2 complex. PMID: 28441586
  7. Interferonstimulated gene factor 3 complex, which consists of STAT1, STAT2 and IRF9, is required for the induction of SAMHD1 expression by IFN-alpha in SMMC-7721 cells. PMID: 26397446
  8. U-ISGF3 induced by IFN-lambdas and -beta drives prolonged expression of a set of IFN-stimulated genes during HCV infection PMID: 26216956
  9. IRF9 is a vascular injury-response molecule that promotes VSMC proliferation. IRF9 expression is upregulated during neointima formation. PMID: 25319116
  10. DC-SIGN-induced ISGF3 by fucose-based PAMPs has an essential role in driving IL-27 and subsequent TFH polarization, which might be harnessed for vaccination design PMID: 25278262
  11. IRF9 mediated myocardial reperfusion injury PMID: 25150882
  12. STAT2 and IRF9 overexpression is sufficient to drive interferon-related DNA damage signature expression upon cell crowding. PMID: 25156627
  13. IL6 is an inducer of IRF9 expression in prostate cancer and a sensitizer for the antiproliferative effects of IFNalpha2. PMID: 23913484
  14. The hepatitis C virus (HCV) non-structural 5A (NS5A) protein, which is known to modulate the IFN response, competes with IRF9 for CypA binding and can prevent the formation of IRF9-CypA complexes. PMID: 22902549
  15. HDAC1 and HDAC2 differentially modulate STAT activity in response to IFNalpha2: while they are required for the induction of ISGF3-responsive genes, they impair the transcription of STAT3-dependent genes. PMID: 21957129
  16. Western blot and electrophoretic mobility-shift assays identified the interferon-stimulated gene factor-3 (ISGF-3) components STAT1 and IRF-9 as the proximal targets of human herpesvirus 8 vIRF-2 activity. PMID: 21697347
  17. STAT2 may interact with IRF-9 in a STAT1-independent manner. The complex STAT2/IRF-9 is the key factor mediating the expression of RIG-G gene regulated by IFN-alpha. PMID: 20403236
  18. Signals ensued by IFN-alpha and IL-4 induce cytoplasmic sequestration of IL-4-activated STAT6 and IFN-alpha-activated STAT2:p48 in B cells through the formation of pY-STAT6:pY-STAT2:p48 complex. PMID: 21268015
  19. analysis of IFN-stimulated response elements (ISREs) that bind to both the IFN-stimulated gene factor 3 (ISGF3) as well as to IFN response factor 7 (IRF7) PMID: 20943654
  20. Results suggest that the amount of cellular IRF9 is a crucial determinant for amplification of early dynamics of IFNalpha-mediated signal transduction. PMID: 20964804
  21. a key factor for eliciting the antiproliferative activity of IFN-alpha in tumors PMID: 19752753
  22. NOD1 can activate the ISGF3 signaling pathway that is usually associated with protection against viral infection to provide robust type I IFN-mediated protection from H. pylori and possibly other mucosal infections PMID: 20389019
  23. the IFN-activated ISGF3 transcription factor regulates transcription through contact with DRIP150 PMID: 12509459
  24. IRF9 functions to recruit RNA polymerase II to the promoter of interferon-stimulated genes and requires histone deacetylases PMID: 15194680
  25. the conserved DNA-binding domain of STAT2 has a role specific to the activity of ISGF3-independent STAT2-containing complexes PMID: 15668228
  26. defects in ISGF3 can cause resistance to IFN-alpha(2a) treatment PMID: 15714000
  27. GBF1 is recruited to the endogenous IRF-9 promoter, and interacts with C/EBP-beta, IL-1, and IL-6 PMID: 16318580
  28. Pretreatment of Huh-7 cells with 0.5-1 mM H2O2 resulted in the suppression of the IFN-alpha-induced antiviral protein MxA and of IRF-9 mRNA expression. PMID: 16595158
  29. Data reveal the existence of a collection of GAS-regulated target genes whose expression is interferon-inducible and independent of ISGF3 but highly dependent on the STAT2 DNA binding domain. PMID: 16689942
  30. Results identify Viperin as a tightly regulated ISGF3 target gene, which is counter-regulated by PRDI-BF1. PMID: 16849320
  31. Suggest that the JAK-STAT pathway may play a major role in mediating the effects of IFN-alpha against hepatitis b virus, and that ISGF3 might be a key factor. PMID: 17559358
  32. These data define the role of the ISGF3 members in IFN-beta inhibitory signaling. PMID: 18370868
  33. The data suggest that liberation of the IFNaR2-ICD by regulated proteolysis could trigger a novel mechanism for moving the transcription factor Stat2 to the nucleus. PMID: 18456457

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Subcellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Protein Families IRF family
Database Links

HGNC: 6131

OMIM: 147574

KEGG: hsa:10379

STRING: 9606.ENSP00000380073

UniGene: Hs.1706

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