IRX4 Antibody

Code CSB-PA011836LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: MCF-7 whole cell lysate, Jurkat whole cell lysate, Colo320 whole cell lysate
    All lanes: IRX4 antibody at 3µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 55, 58 kDa
    Observed band size: 55 kDa

  • Immunofluorescence staining of MCF-7 cells with CSB-PA011836LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IRX4 Polyclonal antibody
Uniprot No.
Target Names
IRX4
Alternative Names
Homeodomain protein IRXA3 antibody; Iroquois homeobox protein 4 antibody; Iroquois-class homeodomain protein IRX-4 antibody; Iroquoisclass homeodomain protein IRX4 antibody; Irx4 antibody; IRX4_HUMAN antibody; IRXA3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Iroquois-class homeodomain protein IRX-4 protein (287-363AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The IRX4 Antibody (Product code: CSB-PA011836LA01HU) is Non-conjugated. For IRX4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA011836LB01HU IRX4 Antibody, HRP conjugated ELISA
FITC CSB-PA011836LC01HU IRX4 Antibody, FITC conjugated
Biotin CSB-PA011836LD01HU IRX4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The IRX4 antibody can be used to recognize the human IRX4 protein. A rabbit got immunization with the recombinant human IRX4 protein (287-363aa). After that, an immune response occurred in the rabbit producing large amounts of antibodies against the IRX4 protein. The rabbit's blood was collected and isolated to get the anti-serum, which was protein G-purified to obtain the IRX4 polyclonal antibody (purity 95%+). This IRX4 antibody has accessed its specificity in ELISA, WB, and IF applications.

The IRX4 plays a crucial role in cardiac development and is essential for proper heart function. Specifically, IRX4 is involved in regulating the differentiation of cardiac conduction cells, which are specialized cells that help coordinate the rhythmic contraction of the heart muscle. Mutations in IRX4 have been linked to several heart conditions, including atrial fibrillation and ventricular tachycardia.

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Target Background

Function
Likely to be an important mediator of ventricular differentiation during cardiac development.
Gene References into Functions
  1. We independently validated IRX4 as a potential prostate cancer risk gene through cis-expression quantitative trait loci analysis of prostate cancer risk variants. PMID: 24022300
  2. the prostate cancer (PC)-susceptibility locus represented by rs12653946 at 5p15 is likely to regulate IRX4 expression in prostate which could suppress PC growth by interacting with the VDR pathway, conferring to PC susceptibility PMID: 22323358
  3. IRX4 had a potential causative impact on the development of congenital heart disease, particularly ventricular septal defect. PMID: 21544582
  4. Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke. PMID: 21779381
  5. Polymorphism A381>G of the Irx4 gene may have a modifier effect on septal thickness, resulting in increased corrected QT dispersion and higher outflow gradients. PMID: 18497553

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Subcellular Location
Nucleus.
Protein Families
TALE/IRO homeobox family
Tissue Specificity
Predominantly expressed in cardiac ventricles.
Database Links

HGNC: 6129

OMIM: 606199

KEGG: hsa:50805

STRING: 9606.ENSP00000231357

UniGene: Hs.196927

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