IRX4 Antibody, HRP conjugated

Code CSB-PA011836LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IRX4 Polyclonal antibody
Uniprot No.
Target Names
IRX4
Alternative Names
Homeodomain protein IRXA3 antibody; Iroquois homeobox protein 4 antibody; Iroquois-class homeodomain protein IRX-4 antibody; Iroquoisclass homeodomain protein IRX4 antibody; Irx4 antibody; IRX4_HUMAN antibody; IRXA3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Iroquois-class homeodomain protein IRX-4 protein (287-363AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Likely to be an important mediator of ventricular differentiation during cardiac development.
Gene References into Functions
  1. We independently validated IRX4 as a potential prostate cancer risk gene through cis-expression quantitative trait loci analysis of prostate cancer risk variants. PMID: 24022300
  2. the prostate cancer (PC)-susceptibility locus represented by rs12653946 at 5p15 is likely to regulate IRX4 expression in prostate which could suppress PC growth by interacting with the VDR pathway, conferring to PC susceptibility PMID: 22323358
  3. IRX4 had a potential causative impact on the development of congenital heart disease, particularly ventricular septal defect. PMID: 21544582
  4. Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke. PMID: 21779381
  5. Polymorphism A381>G of the Irx4 gene may have a modifier effect on septal thickness, resulting in increased corrected QT dispersion and higher outflow gradients. PMID: 18497553

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Subcellular Location
Nucleus.
Protein Families
TALE/IRO homeobox family
Tissue Specificity
Predominantly expressed in cardiac ventricles.
Database Links

HGNC: 6129

OMIM: 606199

KEGG: hsa:50805

STRING: 9606.ENSP00000231357

UniGene: Hs.196927

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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