IST1 Antibody, FITC conjugated

Code CSB-PA012171LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IST1 Polyclonal antibody
Uniprot No.
Target Names
IST1
Alternative Names
hIST1 antibody; Increased sodium tolerance 1 antibody; Increased sodium tolerance 1 homolog antibody; IST1 homolog antibody; IST1_HUMAN antibody; KIAA0174 antibody; MAPK activating protein PM28 antibody; MGC117220 antibody; MGC128433 antibody; Putative MAPK-activating protein PM28 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human IST1 homolog protein (172-284AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.
Gene References into Functions
  1. Nuclear overexpression of OLC1 was associated with clinicopathological parameters and could predict a poor overall survival in gastric adenocarcinoma. PMID: 28038462
  2. The expression of OLC1 in the tumor tissues of lung adenocarcinoma is higher than that in squamous cell carcinoma. PMID: 28532543
  3. Structural and biochemical studies reveal an unusually tight interaction between ULK3 and IST1, an ESCRT-III subunit required for cytokinetic abscission. PMID: 26011858
  4. Overexpression of OLC1 promotes tumorigenesis of human esophageal squamous cell carcinoma. PMID: 24608342
  5. Findings indicate that a high expression level of overexpressed in lung cancer 1 (OLC1) serves as a biomarker for poor prognosis for breast cancer, suggesting that OLC1 may be a potential target of antiangiogenic therapy for breast cancer. PMID: 24880589
  6. Over-expression of the OCL1 is associated with colorectal cancer. PMID: 24403489
  7. the binding of ALG-2 to IST1 is Ca(2+)-dependent PMID: 23649269
  8. The results suggest that inclusion of IST1 into the ESCRT complex allows recruitment of spastin to promote fission of recycling tubules from the endosome. PMID: 23897888
  9. OLC1 over-expression is an important factor in epithelial ovarian carcinoma prognosis and can be a potential biomarker for ovarian carcinoma. PMID: 23609236
  10. The interaction between CL7MIT and CHMP1B and between CL7MIT and IST1 became stronger when IST1 or CHMP1B was additionally coexpressed, suggesting formation of ternary complex of calpain-7, IST1 and CHMP1B. PMID: 21616915
  11. These results demonstrate that cigarette smoke regulates OLC1 expression in lung cancer cells by compromising its ubiquitination and subsequent degradation through the ubiquitin E3 ligase APC. PMID: 21439932
  12. These data suggest that Ist1 interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis. PMID: 20719964
  13. Results demonstrate that human calpain 7 is proteolytically active, and imply that calpain 7 is activated by ESCRT-III-related protein IST1. PMID: 20849418
  14. OLC1 (KIAA0174) is a candidate oncogene in lung cancer whose expression may be regulated by exposure to cigarette smoke. PMID: 19001599
  15. IST1 and CHMP1 act together to recruit and modulate specific VPS4 activities required during the final stages of cell division. PMID: 19129479
  16. hIST1 is essential for cytokinesis in mammalian cells. PMID: 19129480
  17. Data show that the N-terminal core domains of increased sodium tolerance-1 (IST1) and charged multivesicular body protein-3 (CHMP3) form equivalent four-helix bundles, revealing that IST1 is a previously unrecognized ESCRT-III family member. PMID: 19525971

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Subcellular Location
Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus envelope.
Protein Families
IST1 family
Database Links

HGNC: 28977

OMIM: 616434

KEGG: hsa:9798

STRING: 9606.ENSP00000330408

UniGene: Hs.232194

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