ITGB5 Antibody

Datasheet
Code CSB-PA197500
Size US$299
Uniprot No. P18084
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA197500(ITGB5 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA197500(ITGB5 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Fusion protein of Human ITGB5
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,IHC;ELISA:1:1000-1:5000,IHC:1:25-1:100
Relevance Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias integrin, beta 5
Immunogen Species Homo sapiens (Human)
Target Names ITGB5
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Integrin alpha-V/beta-5 (ITGAV
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Integrin beta chain family
Database Links

HGNC: 6160

OMIM: 147561

KEGG: hsa:3693

STRING: 9606.ENSP00000296181

UniGene: Hs.13155

Pathway PI3K-Akt signaling pathway
Focal adhesion
Regulation of actin cytoskeleton

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