ITGB5 Antibody

Code CSB-PA011889LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA011889LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ITGB5 Polyclonal antibody
Uniprot No. P18084
Target Names ITGB5
Alternative Names FLJ26658 antibody; Integrin beta-5 antibody; Integrin subunit beta 5 antibody; integrin, beta 5 antibody; ITB5_HUMAN antibody; Itgb5 antibody; Testis secretory sperm-binding protein Li 217p antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Integrin beta-5 protein (431-637AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Integrin alpha-V/beta-5 (ITGAV
Gene References into Functions
  1. High ITGB5 expression is associated with cervical cancer. PMID: 26758421
  2. FAK activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma. PMID: 24899686
  3. FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 PMID: 25448675
  4. Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 and hypoxia-inducible factor (HIF)-1alpha indexes PMID: 25150423
  5. Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration PMID: 24997346
  6. we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone PMID: 24455718
  7. Brain metastases ITGB5 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
  8. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. PMID: 24036928
  9. molecular model of integrin b5 structure was prepared and stereo chemical model quality was checked. Integrin b5 active sites were identified based on insilico analysis tools. PMID: 23962022
  10. BDNF enhances the migration of chondrosarcoma by increasing beta5 integrin expression through a signal transduction pathway that involves the TrkB receptor, PI3K, Akt, and NF-kappaB. PMID: 23874483
  11. The top primary GWAS association of Airway hyperresponsiveness was in rs848788(P-value 7.2E-07) located within the ITGB5 genes. PMID: 23984888
  12. Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells PMID: 22824793
  13. High beta5-integrin protein expression is associated with aggressive behavior in gastric cancer. PMID: 22561002
  14. Letter: loss of integrin beta5 in polyomavirus positive Merkel cell carcinoma may influence cell adhesion/migration. PMID: 22503669
  15. Cysteine-rich protein Cyr61 activates interleukin (IL)-6 production via the alphavbeta5/Akt/NF-kappaB signaling pathway in rheumatoid arthritis. PMID: 22547695
  16. The beta5-integrin adhesions contribute to the TGFbeta-induced EMT and the tumorigenic potential of carcinoma cells. PMID: 20404485
  17. p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration PMID: 20507994
  18. Src kinase-mediated activation of STAT3 and subsequent angiogenic gene expression mediate the effects of integrin alpha v beta 5 and may be exploited to enhance the paracrine activities of circulating angiogenic cells. PMID: 20431064
  19. Overexpression of the beta5 integrin in hematopoietic cells was associated with the inhibition of cell proliferation and apoptosis. PMID: 11877043
  20. different beta5 integrins: repeated-FNK (FNKFNK764-769) and single-FNK (FNK764-766) amino acid sequences in the cytoplasmic domain. PMID: 15979906
  21. Our studies suggest that the phagocytic function of beta5 integrin is regulated by an unconventional NPxY-talin-independent activation signal and argue for the existence of molecular switches in the beta5 cytoplasmic tail for adhesion and phagocytosis. PMID: 17963729

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Integrin beta chain family
Database Links

HGNC: 6160

OMIM: 147561

KEGG: hsa:3693

STRING: 9606.ENSP00000296181

UniGene: Hs.13155

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