ITSN1 Antibody, HRP conjugated

1. WIP enhances the interaction of N-WASP with ITSN1 and promotes ITSN1/beta-actin association. PMID: 29958948
2. Here, we discover that intersectin-s binds DENND2B, a guanine nucleotide exchange factor for the exocytic GTPase Rab13, and this interaction promotes recycling of ligand-free EGFR to the cell surface. Our study thus reveals a novel mechanism controlling the fate of internalized EGFR with important implications for cancer. PMID: 29030480
3. study reports that vaccinia virus A36 contains three NPF motifs that interact with the Eps15 homology (EH) domains in intersectin-1 and Eps15 to promote the release of virus from infected cells and their subsequent spread PMID: 27670116
4. Silencing ITSN1 in neuroblastoma cells led to decreased tumor growth in an orthotopic mouse model. Orthotopic animal models can provide insight into the role of ITSN1 pathways in neuroblastoma tumorigenesis. PMID: 28787396
5. These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion. PMID: 28161632
6. Abnormal expression of the intersectin1-L protein in epileptic brain tissue may play an important role in epilepsy, especially refractory epilepsy. PMID: 25783631
7. Study suggests critical roles of ITSN1-S in malignant glioma proliferation, indicating a potential usage of ITSN1-S in the therapeutic intervention as a novel molecular target PMID: 25832561
8. Our observations suggest that ITSN1 is an important general regulator of Cdc42-, Nck- and N-WASP-dependent actin polymerisation PMID: 24284073
9. ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins. PMID: 23936226
10. Silencing ITSN1 significantly inhibits the anchorage independent growth of tumor cells in vitro. PMID: 22266851
11. the neuron-specific isoform of the stable tubule-only polypeptide (STOP) interacts with SH3A domain of ITSN1. PMID: 22750298
12. ITSN-1s, via its SH3A domain has the unique ability to regulate dyn2 assembly-disassembly and function during endocytosis PMID: 21129155
13. ITSN1 has two isoforms: ITSN1-long and ITSN1-short. siRNA-mediated down regulation of ITSN1-short inhibits migration and invasion of glioma cells. PMID: 21503949
14. study reveals a link between overexpression of specific ITSN1 isoforms and behavioral phenotypes PMID: 21876463
15. This novel mammalian ITSN1 isoform possesses a significantly altered domain structure and performs specific protein-protein interactions. PMID: 21712076
16. Downregulation of intersectin-1s induces apoptosis of brain glioblastoma cells. PMID: 20493827
17. Studied the inhibitory mechanism of ITSN1L, & id'd a novel short amino acid motif which mediates autoinhibition. Found this motif is located in the SH3 DH linker region, and show that W1221 acts as key residue in establishing inhibitory interaction. PMID: 20842712
18. These findings expand the role of ITSN1 as a scaffolding molecule bringing together components of endocytic complexes. PMID: 20946875
19. The identification of fifteen novel transcriptional isoforms of the human ITSN1 gene with full-length coding sequences , is reported. PMID: 19777371
20. microexons provide a mechanism for the control of tissue-specific interactions of ITSN1 and Src with their partners. PMID: 20659428
21. intersectin interaction with dynamin was important in regulating the fission and internalization of caveolae PMID: 12960435
22. review of roles of ITSN1 and DSCR1 in Down syndrome, Alzheimer's disease, endocytosis and vesicle trafficking PMID: 16442855
23. Results extend the current role of intersectin-1L in endocytosis to a function in exocytosis and support the idea that intersectin-1L is an adaptor that coordinates exo-endocytotic membrane trafficking in secretory cells. PMID: 16874303
24. ITSN forms a complex with Cbl in vivo mediated by the Src homology (SH) 3 domains binding to the Pro-rich COOH terminus of Cbl. This interaction stimulates the ubiquitylation and degradation of the activated EGFR. PMID: 16914641
25. findings demonstrate a novel role of ITSN-1s as a negative regulator of the mitochondrial pathway-dependent apoptosis secondary to activation of the Erk1/2 survival signaling pathway PMID: 17405881
26. These results demonstrate that alternative splicing leads to the formation of two pools of ITSN1 with potentially different properties in neurons, affecting ITSN1 function as adaptor protein. PMID: 18539136
27. These data provide a molecular link between SHIP2 and ITSN1 which are involved in receptor endocytosis regulation. PMID: 18692052
28. Intersectin 1 forms a complex with adaptor protein (SH3KBP1 protein), implicated in downregulation of receptor tyrosine kinases. PMID: 19166927
29. The higher exchange activity of ITSN1L towards the GDP-bound conformation of Cdc42 could represent an evolutionary adaptation of this GEF that ensures nucleotide exchange towards the formation of the signalling-active GTP-bound form of Cdc42. PMID: 19356586

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HGNC: 6183

OMIM: 602442

KEGG: hsa:6453

STRING: 9606.ENSP00000370719

UniGene: Hs.160324