ITSN2 Antibody, FITC conjugated

1. These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion. PMID: 28161632
2. ITSN2L interacts with RABEP1 and stimulates its degradation in regulation of endocytosis. PMID: 26633357
3. The ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins. PMID: 22449706
4. ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins. PMID: 23936226
5. The sequence and structural alignment of ITSN-2L C2 domain with other members of C2 domain protein family indicate its vital cellular roles in membrane trafficking, the generation of lipid-second messengers and activation of GTPases. Moreover, our data show the possible roles of ITSN-2L C2 domain in regulating the activity of Cdc42. PMID: 23274495
6. These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2. PMID: 16394100
7. ITSN2C may be specifically expressed in neurons hinting to a physiologic role in neuronal cell function. PMID: 17390067
8. We show that the PPLP motif of K15 protein selectively binds the SH3-C domain of an endocytic adaptor protein, Intersectin 2 (ITSN2). PMID: 17696407
9. ITSN-2L, a guanine nucleotide exchange factor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane. PMID: 19622753

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HGNC: 6184

OMIM: 604464

KEGG: hsa:50618

STRING: 9606.ENSP00000347244

UniGene: Hs.432562