IYD Antibody, HRP conjugated

Code CSB-PA754272LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IYD Polyclonal antibody
Uniprot No.
Target Names
IYD
Alternative Names
IYD antibody; C6orf71 antibody; DEHAL1 antibody; Iodotyrosine deiodinase 1 antibody; IYD-1 antibody; EC 1.21.1.1 antibody; Iodotyrosine dehalogenase 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Iodotyrosine deiodinase 1 protein (24-147AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
Gene References into Functions
  1. The rate-limiting processes that contribute to the ability of flavin to promote reductive dehalogenation in human IYD. PMID: 26151430
  2. A switch between one- and two-electron chemistry of iodotyrosine deiodinase is controlled by substrate. PMID: 25395621
  3. Iodotyrosine deiodinase defect identified via genome-wide approach. PMID: 22535972
  4. high activity of human saliva peroxidase with iodide as a substrate may play a crucial role in the bioavailability and metabolism of biologically active iodide. PMID: 21870604
  5. Mutations in DEHAL1 leads to hypothyroidism, goiter and mental retardation (Review) PMID: 20298747
  6. molecular cloning and investigation of the localization and activity of DEHAL1 PMID: 15289438
  7. the cytoplasmic tail of DEHAL1 could play a role in the stability of the protein PMID: 16910871
  8. Diffuse cytoplasmatic localisation or downregulation of DEHAL1 expression in thyroid cancers suggests alteration or loss of DEHAL1 function during thyroid cell dedifferentiation. PMID: 17322488
  9. homozygous mutations in DEHAL1 appear to cause human iodotyrosine deiodinase deficiency, leading to hereditary hypothyroidism and goiter PMID: 18434651
  10. This study describes a functional mutation within IYD, demonstrating the molecular basis of the iodine wasting form of congenital hypothyroidism PMID: 18765512

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Involvement in disease
Thyroid dyshormonogenesis 4 (TDH4)
Subcellular Location
Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.
Protein Families
Nitroreductase family
Tissue Specificity
Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
Database Links

HGNC: 21071

OMIM: 274800

KEGG: hsa:389434

STRING: 9606.ENSP00000229447

UniGene: Hs.310225

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