IYD Antibody

1. The rate-limiting processes that contribute to the ability of flavin to promote reductive dehalogenation in human IYD. PMID: 26151430
2. A switch between one- and two-electron chemistry of iodotyrosine deiodinase is controlled by substrate. PMID: 25395621
3. Iodotyrosine deiodinase defect identified via genome-wide approach. PMID: 22535972
4. high activity of human saliva peroxidase with iodide as a substrate may play a crucial role in the bioavailability and metabolism of biologically active iodide. PMID: 21870604
5. Mutations in DEHAL1 leads to hypothyroidism, goiter and mental retardation (Review) PMID: 20298747
6. molecular cloning and investigation of the localization and activity of DEHAL1 PMID: 15289438
7. the cytoplasmic tail of DEHAL1 could play a role in the stability of the protein PMID: 16910871
8. Diffuse cytoplasmatic localisation or downregulation of DEHAL1 expression in thyroid cancers suggests alteration or loss of DEHAL1 function during thyroid cell dedifferentiation. PMID: 17322488
9. homozygous mutations in DEHAL1 appear to cause human iodotyrosine deiodinase deficiency, leading to hereditary hypothyroidism and goiter PMID: 18434651
10. This study describes a functional mutation within IYD, demonstrating the molecular basis of the iodine wasting form of congenital hypothyroidism PMID: 18765512

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HGNC: 21071

OMIM: 274800

KEGG: hsa:389434

STRING: 9606.ENSP00000229447

UniGene: Hs.310225