IYD Antibody

Code CSB-PA754272LA01HU
Size US$166
Order now
Image
  • Immunofluorescence staining of A549 cells with CSB-PA754272LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IYD Polyclonal antibody
Uniprot No.
Target Names
IYD
Alternative Names
IYD antibody; C6orf71 antibody; DEHAL1 antibody; Iodotyrosine deiodinase 1 antibody; IYD-1 antibody; EC 1.21.1.1 antibody; Iodotyrosine dehalogenase 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Iodotyrosine deiodinase 1 protein (24-147AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The IYD Antibody (Product code: CSB-PA754272LA01HU) is Non-conjugated. For IYD Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA754272LB01HU IYD Antibody, HRP conjugated ELISA
FITC CSB-PA754272LC01HU IYD Antibody, FITC conjugated
Biotin CSB-PA754272LD01HU IYD Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
Gene References into Functions
  1. The rate-limiting processes that contribute to the ability of flavin to promote reductive dehalogenation in human IYD. PMID: 26151430
  2. A switch between one- and two-electron chemistry of iodotyrosine deiodinase is controlled by substrate. PMID: 25395621
  3. Iodotyrosine deiodinase defect identified via genome-wide approach. PMID: 22535972
  4. high activity of human saliva peroxidase with iodide as a substrate may play a crucial role in the bioavailability and metabolism of biologically active iodide. PMID: 21870604
  5. Mutations in DEHAL1 leads to hypothyroidism, goiter and mental retardation (Review) PMID: 20298747
  6. molecular cloning and investigation of the localization and activity of DEHAL1 PMID: 15289438
  7. the cytoplasmic tail of DEHAL1 could play a role in the stability of the protein PMID: 16910871
  8. Diffuse cytoplasmatic localisation or downregulation of DEHAL1 expression in thyroid cancers suggests alteration or loss of DEHAL1 function during thyroid cell dedifferentiation. PMID: 17322488
  9. homozygous mutations in DEHAL1 appear to cause human iodotyrosine deiodinase deficiency, leading to hereditary hypothyroidism and goiter PMID: 18434651
  10. This study describes a functional mutation within IYD, demonstrating the molecular basis of the iodine wasting form of congenital hypothyroidism PMID: 18765512

Show More

Hide All

Involvement in disease
Thyroid dyshormonogenesis 4 (TDH4)
Subcellular Location
Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.
Protein Families
Nitroreductase family
Tissue Specificity
Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
Database Links

HGNC: 21071

OMIM: 274800

KEGG: hsa:389434

STRING: 9606.ENSP00000229447

UniGene: Hs.310225

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*