JAGN1 Antibody

Datasheet

Code	CSB-PA818709LA01HU
Size	US$166
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Image	Western blot All lanes: JAGN1 antibody at 3µg/ml + HL60 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 22 kDa Observed band size: 22 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA818709LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA818709LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA818709LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) JAGN1 Polyclonal antibody

Uniprot No.

Q8N5M9

Target Names

JAGN1

Alternative Names

JAGN1; Protein jagunal homolog 1

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein jagunal homolog 1 protein (1-39AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The JAGN1 Antibody (Product code: CSB-PA818709LA01HU) is Non-conjugated. For JAGN1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA818709LB01HU	JAGN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA818709LC01HU	JAGN1 Antibody, FITC conjugated
Biotin	CSB-PA818709LD01HU	JAGN1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.

Gene References into Functions

JAGN1 participates in the secretory pathway and is required for granulocyte colony-stimulating factor receptor-mediated signaling. JAGN1 emerges as a factor that is necessary in the differentiation and survival of neutrophils. PMID: 25129144
Data directly identify Jagn1 (JAGN1 in humans) as a new regulator of neutrophil function in microbial pathogenesis. PMID: 25129145

Involvement in disease

Neutropenia, severe congenital 6, autosomal recessive (SCN6)

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

Jagunal family

Tissue Specificity

Ubiquitously expressed.

Database Links

HGNC: 26926

OMIM: 616012

KEGG: hsa:84522

STRING: 9606.ENSP00000306106

UniGene: Hs.24054

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Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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