JAGN1 Antibody, HRP conjugated

Code CSB-PA818709LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) JAGN1 Polyclonal antibody
Uniprot No.
Target Names
JAGN1
Alternative Names
JAGN1; Protein jagunal homolog 1
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein jagunal homolog 1 protein (1-39AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.
Gene References into Functions
  1. JAGN1 participates in the secretory pathway and is required for granulocyte colony-stimulating factor receptor-mediated signaling. JAGN1 emerges as a factor that is necessary in the differentiation and survival of neutrophils. PMID: 25129144
  2. Data directly identify Jagn1 (JAGN1 in humans) as a new regulator of neutrophil function in microbial pathogenesis. PMID: 25129145
Involvement in disease
Neutropenia, severe congenital 6, autosomal recessive (SCN6)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
Jagunal family
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 26926

OMIM: 616012

KEGG: hsa:84522

STRING: 9606.ENSP00000306106

UniGene: Hs.24054

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