JAKMIP1 Antibody

Code CSB-PA011933GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
JAKMIP1
Alternative Names
FLJ31564 antibody; GABA B receptor binding protein antibody; GABA-B receptor-binding protein antibody; GABABRBP antibody; Jak and microtubule interacting protein 1 antibody; JAKMIP 1 antibody; JAKMIP1 antibody; JAMIP1 antibody; Janus kinase and microtubule interacting protein 1 antibody; Janus kinase and microtubule-interacting protein 1 antibody; JKIP1_HUMAN antibody; Marlin 1 antibody; Marlin-1 antibody; MARLIN1 antibody; Multiple alpha-helices and RNA-linker protein 1 antibody; Multiple coiled coil GABABR1 binding protein antibody; OTTHUMP00000155144 antibody; OTTHUMP00000203209 antibody; OTTHUMP00000203210 antibody; OTTHUMP00000203212 antibody; OTTHUMP00000217225 antibody; OTTHUMP00000217781 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human JAKMIP1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
Gene References into Functions
  1. JAKMIP1 associates with and possibly contributes to the Wnt/beta-catenin pathway activity through its influence on downstream Wnt target proteins, including beta-catenin. PMID: 23481296
  2. Marlin-1 functions to regulate the cellular levels of GABA(B) R2 subunits, which may have significant effects on the production of functional GABA(B) receptor heterodimers PMID: 14718537
  3. Marlin1 has a role in cell polarization, segregation of signaling complexes, and vesicle traffic, some of which may involve Jak tyrosine kinases PMID: 15277531
  4. We have identified four new transcripts of 2975 bp, 1743 bp, 2189 bp and 2420 bp respectively, named Jakmip1B, Jakmip1C, Jakmip1D and Jakmip1E PMID: 17761393
  5. Jakmip1 is a novel effector memory gene that restrains T cell-mediated cytotoxicity. PMID: 18941173

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Subcellular Location
Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.
Protein Families
JAKMIP family
Tissue Specificity
Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected
Database Links

HGNC: 26460

OMIM: 611195

KEGG: hsa:152789

STRING: 9606.ENSP00000386711

UniGene: Hs.479066

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