KALRN Antibody, FITC conjugated

Datasheet
Code CSB-PA011981LC01HU
Size US$299
Uniprot No. O60229
Protocols ELISA Protocol
Immunogen Recombinant Human Kalirin protein (2410-2661AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain), KALRN, DUET DUO HAPIP TRAD
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names KALRN
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Involvement in disease Coronary heart disease 5 (CHDS5)
Subcellular Location Cytoplasm, Cytoplasm, cytoskeleton
Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Tissue Specificity Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
Database Links

HGNC: 4814

OMIM: 604605

KEGG: hsa:8997

STRING: 9606.ENSP00000240874

UniGene: Hs.13281

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