KCNJ12 Antibody, HRP conjugated

1. Cellular electrophysiology assays of mouse Kir2.1 and human Kir2.2 indicated that, consistent with simulations, the Leu residue increased the channel responses to phosphatidylinositol diphosphate (PIP2) through increased binding affinity and faster activation kinetics, and the deactivation kinetics decreased upon PIP2 inhibition. PMID: 26520451
2. This report is the first to describe the KCNJ12 gene as a cause of familial dilated cardiomyopathy in patients PMID: 28816949
3. The augmentation of Ca(2+) influx and cytokine release suggests a physiological role for Kir2.2 in TLR4-stimulated monocytes. PMID: 26324774
4. Unconventional role of the inwardly rectifying potassium channel Kir2.2 as a constitutive activator of RelA in cancer. PMID: 23269273
5. Kir2.2 knockdown induces senescence of cancer cells by a mechanism involving reactive oxygen species accumulation. PMID: 20841375
6. heteromerization contributes to the phenotype of Andersen syndrome PMID: 12032359
7. Molecular cloning of functional KCNJ12 with an arginine residue at position 285. PMID: 12417321
8. transcripts for Kir2.2 potassium channels are identified in proliferative smooth muscle cells PMID: 12598232
9. Data show that the recovery of K(ir)2.2 from inhibition by FCCP requires intracellular components, but direct depletion of ATP does not reproduce the differential inhibitory effect of FCCP. PMID: 19016473

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HGNC: 6258

OMIM: 602323

KEGG: hsa:3768

STRING: 9606.ENSP00000328150

UniGene: Hs.200629