KCNJ16 (Ab-416) Antibody

Code CSB-PA281454
Size US$297
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  • Western blot analysis of extracts from HeLa cells, using Kir5.1 (Ab-416) antibody.
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue using Kir5.1 (Ab-416) antibody.
  • Immunofluorescence analysis of HeLa cells, using Kir5.1 (Ab-416) antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KCNJ16 Polyclonal antibody
Uniprot No.
Target Names
KCNJ16
Alternative Names
KCNJ16; Inward rectifier potassium channel 16; Inward rectifier K(+ channel Kir5.1; Potassium channel, inwardly rectifying subfamily J member 16
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized non-phosphopeptide derived from Human Kir5.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
Gene References into Functions
  1. HNF1beta is a transcriptional activator of Kcnj16. Hence, patients with HNF1beta mutations may have reduced Kir5.1 activity in the kidney, resulting in hypokalemia and hypomagnesemia. PMID: 28577853
  2. Gene expression levels of three randomly selected DEGs, VCAN, COL5A1 and KCNJ16, were examined using RT-PCR in 10 ATC samples.. angiogenesis was activated by the high expression of CTHRC1, VCAN and POSTN, providing necessary nutrition for tumor cells PMID: 27599582
  3. Five de novo mutations were identified in four genes (SCNN1A, KCNJ16, KCNB2, and KCNT1) in three Brugada syndrome patients PMID: 25339316
Subcellular Location
Membrane; Multi-pass membrane protein. Basolateral cell membrane.
Protein Families
Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ16 subfamily
Tissue Specificity
Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.
Database Links

HGNC: 6262

OMIM: 605722

KEGG: hsa:3773

STRING: 9606.ENSP00000283936

UniGene: Hs.463985

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