KCNRG Antibody, Biotin conjugated

Code CSB-PA847638LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KCNRG Polyclonal antibody
Uniprot No.
Target Names
KCNRG
Alternative Names
KCNRG antibody; CLLD4Potassium channel regulatory protein antibody; Potassium channel regulator antibody; Protein CLLD4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Potassium channel regulatory protein (1-229AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
Gene References into Functions
  1. The haploinsufficiency of KCNRG might be relevant to the progression of chronic lymphocytic leukemia (CLL)and multiple myeloma(MM) at least in a subset of patients. PMID: 20237900
  2. KCNRG is an ER-associated protein, which is proposed to regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. PMID: 19968958
  3. the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3; is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene PMID: 12650944
  4. Results suggest that genetic alterations and the expression of KCNRG might play an important role in the development and/or progression of a subset of hepatocellular carcinoma. PMID: 16819283
  5. Autoantibodies to KCNRG were present in 7 of the 8 patients with respiratory symptoms in autoimmune polyendocrine syndrome type 1 PMID: 19251657
  6. KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. PMID: 12650944

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Subcellular Location
Endoplasmic reticulum.
Tissue Specificity
Ubiquitous in normal tissues and expressed in some tumor tissues.
Database Links

HGNC: 18893

OMIM: 607947

KEGG: hsa:283518

STRING: 9606.ENSP00000324191

UniGene: Hs.660161

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