KCNRG Antibody, Biotin conjugated

Code CSB-PA847638LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KCNRG Polyclonal antibody
Uniprot No.
Target Names
KCNRG
Alternative Names
KCNRG antibody; CLLD4Potassium channel regulatory protein antibody; Potassium channel regulator antibody; Protein CLLD4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Potassium channel regulatory protein (1-229AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
Gene References into Functions
  1. The haploinsufficiency of KCNRG might be relevant to the progression of chronic lymphocytic leukemia (CLL)and multiple myeloma(MM) at least in a subset of patients. PMID: 20237900
  2. KCNRG is an ER-associated protein, which is proposed to regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. PMID: 19968958
  3. the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3; is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene PMID: 12650944
  4. Results suggest that genetic alterations and the expression of KCNRG might play an important role in the development and/or progression of a subset of hepatocellular carcinoma. PMID: 16819283
  5. Autoantibodies to KCNRG were present in 7 of the 8 patients with respiratory symptoms in autoimmune polyendocrine syndrome type 1 PMID: 19251657
  6. KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. PMID: 12650944

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Subcellular Location
Endoplasmic reticulum.
Tissue Specificity
Ubiquitous in normal tissues and expressed in some tumor tissues.
Database Links

HGNC: 18893

OMIM: 607947

KEGG: hsa:283518

STRING: 9606.ENSP00000324191

UniGene: Hs.660161

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