KDM1B Antibody

Datasheet

Code	CSB-PA822748LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA822748LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA822748LA01HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KDM1B Polyclonal antibody

Uniprot No.

Q8NB78

Target Names

KDM1B

Alternative Names

amine oxidase (flavin containing) domain 1 antibody; amine oxidase, flavin containing 1 antibody; AOF1 antibody; bA204B7.3 antibody; C6orf193 antibody; dJ298J15.2 antibody; Flavin-containing amine oxidase domain-containing protein 1 antibody; FLJ33898 antibody; FLJ34109 antibody; FLJ43328 antibody; KDM1B antibody; KDM1B_HUMAN antibody; LSD2 antibody; lysine (K)-specific demethylase 1B antibody; Lysine-specific demethylase 2 antibody; Lysine-specific histone demethylase 1B antibody; Lysine-specific histone demethylase 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Lysine-specific histone demethylase 1B protein (451-544AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The KDM1B Antibody (Product code: CSB-PA822748LA01HU) is Non-conjugated. For KDM1B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA822748LB01HU	KDM1B Antibody, HRP conjugated	ELISA
FITC	CSB-PA822748LC01HU	KDM1B Antibody, FITC conjugated
Biotin	CSB-PA822748LD01HU	KDM1B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.

Gene References into Functions

These results suggest that LSD2 achieves a promoting effect on small cell lung cancer by indirectly regulating TFPI2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPI2 gene. PMID: 29845195
This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes. PMID: 28277979
These results demonstrate an important role for LSD2 in regulation of DNA methylation and gene silencing in breast cancer. PMID: 24924415
Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT. PMID: 25773598
Using transcriptome and chromatin immunoprecipitation-sequencing analyses, the study revealed that LSD2 represses the genes involved in lipid influx and metabolism through demethylation of histone H3K4. PMID: 25624347
regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 PMID: 25036127
The zinc finger-SWIRM-oxidase domains is required for KDM1B demethylase activity and the binding of FAD. PMID: 23266887
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. PMID: 20670891

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Subcellular Location

Nucleus.

Protein Families

Flavin monoamine oxidase family

Database Links

HGNC: 21577

OMIM: 613081

KEGG: hsa:221656

STRING: 9606.ENSP00000297792

UniGene: Hs.709336

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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