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| Code | CSB-RA958367A0HU |
| Size | US$210 |
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| Application | Recommended Dilution |
|---|---|
| WB | 1:500-1:2000 |
The creation of the KDM1B recombinant monoclonal antibody involves a complex process with several steps. To begin with, the KDM1B monoclonal antibody is harvested, and its gene sequence is determined. Following that, a vector containing the KDM1B monoclonal antibody gene is constructed and transfected into a host cell line for culture. A synthesized peptide, which is derived from human KDM1B, is utilized as an immunogen during KDM1B monoclonal antibody synthesis. The KDM1B recombinant monoclonal antibody is purified by affinity chromatography and subjected to analysis for specificity using ELISA and WB applications. It only detects human KDM1B protein.
KDM1B, also known as LSD1, is a lysine-specific demethylase that catalyzes the removal of methyl groups from histone H3 lysine 4 (H3K4) and lysine 9 (H3K9), leading to transcriptional repression. KDM1B plays a role in the regulation of gene expression, embryonic development, and differentiation. It has been implicated in the progression of various diseases, including cancer and neurodegenerative disorders.
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