Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KIDINS220 Polyclonal antibody

Uniprot No.

Q9ULH0

Target Names

KIDINS220

Alternative Names

Ankyrin repeat-rich membrane-spanning protein antibody; arms antibody; KDIS_HUMAN antibody; kidins220 antibody; Kinase D interacting substance of 220 kDa antibody; Kinase D-interacting substrate of 220 kDa antibody; rgd 619949 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kinase D-interacting substrate of 220 kDa protein (1077-1370AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Gene References into Functions

Kidins220 has a prominent role in tumor development by participating in a complex signaling pathways. (Review) PMID: 28849114
The Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. PMID: 27858709
Authors hence propose that the identified homozygous loss-of-function variant in KIDINS220 causes the phenotype in the presented fetuses, and that this represents a hitherto undescribed severe autosomal recessive neurodevelopmental disorder. PMID: 28934391
This work reveals a crucial physiological role of KIDINS220 in development and provides insight into how perturbation of the complex interplay of KIDINS220 isoforms and their relative expression can affect neuron control and human metabolism. Altogether, we here show that de novo protein-truncating KIDINS220 variants cause a new syndrome, SINO. This is the first report of KIDINS220 variants causing a human disease. PMID: 27005418
the existence of novel Kidins220/ARMS splice isoforms with unique properties PMID: 26083449
Our results establish the role of ARMS in microglial activation by HIV Tat PMID: 25636783
Kidins220 is expressed in neuroblastoma tumors and stabilizes NGF-induced, but not BDNF-induced, survival signaling in neuroblastoma cell lines. PMID: 23999075
Kidins220 levels are increased in human brain necropsies from Alzheimer's disease patients. Kidins220 localizes within hyperphosphorylated tau aggregates, and is a substrate for GSK3beta. PMID: 23118350
Kidins220 depletion is associated with the neural-to Schwann-like transition in neuroblastoma. PMID: 23333500
Kidins220 is a novel T-cell receptor (TCR)-interacting protein that couples B-Raf to the TCR. Kidins220 is mandatory for sustained Erk signaling and is crucial for TCR-mediated T cell activation. PMID: 23359496
Kidins220/ARMS is a functional mediator of multiple receptor signalling pathways. PMID: 22562556
a novel partner of Kidins220/ARMS PMID: 22609016
induction of morphological polarization in primary T lymphocytes and Jurkat cells enhances Kidins220/ARMS colocalization with ICAM-3 PMID: 21381019
Ankyrin repeat-rich membrane spanning expression, conjunctly with tumour thickness or ulceration, may serve as a prognostic factor in patients with cutaneous melanoma. PMID: 21343931
endogenous PKD1, PKD2, and Kidins220 co-exist with neurotensin-containing vesicles PMID: 18048355
Down-regulation of ARMS results in inhibition of anchorage-independent growth in soft agar and restrictive growth of melanoma in severe combined immunodeficient mice PMID: 18089783
Ankyrin-rich membrane spanning protein is a major factor that links neurotrophin signaling to nuclear factor-kappa B. PMID: 18501627
sigma-1R overexpression drives sigma agonist-independent dissociation of ANK 220 from IP3R-3, resulting in activation PMID: 18539593

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Involvement in disease

Spastic paraplegia, intellectual disability, nystagmus, and obesity (SINO)

Subcellular Location

Membrane; Multi-pass membrane protein. Late endosome. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.

Tissue Specificity

Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.

Database Links

HGNC: 29508

OMIM: 615759

KEGG: hsa:57498

STRING: 9606.ENSP00000256707

UniGene: Hs.467627