Recombinant Human Kinase D-interacting substrate of 220 kDa (KIDINS220), partial

1. Kidins220 has a prominent role in tumor development by participating in a complex signaling pathways. (Review) PMID: 28849114
2. The Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. PMID: 27858709
3. Authors hence propose that the identified homozygous loss-of-function variant in KIDINS220 causes the phenotype in the presented fetuses, and that this represents a hitherto undescribed severe autosomal recessive neurodevelopmental disorder. PMID: 28934391
4. This work reveals a crucial physiological role of KIDINS220 in development and provides insight into how perturbation of the complex interplay of KIDINS220 isoforms and their relative expression can affect neuron control and human metabolism. Altogether, we here show that de novo protein-truncating KIDINS220 variants cause a new syndrome, SINO. This is the first report of KIDINS220 variants causing a human disease. PMID: 27005418
5. the existence of novel Kidins220/ARMS splice isoforms with unique properties PMID: 26083449
6. Our results establish the role of ARMS in microglial activation by HIV Tat PMID: 25636783
7. Kidins220 is expressed in neuroblastoma tumors and stabilizes NGF-induced, but not BDNF-induced, survival signaling in neuroblastoma cell lines. PMID: 23999075
8. Kidins220 levels are increased in human brain necropsies from Alzheimer's disease patients. Kidins220 localizes within hyperphosphorylated tau aggregates, and is a substrate for GSK3beta. PMID: 23118350
9. Kidins220 depletion is associated with the neural-to Schwann-like transition in neuroblastoma. PMID: 23333500
10. Kidins220 is a novel T-cell receptor (TCR)-interacting protein that couples B-Raf to the TCR. Kidins220 is mandatory for sustained Erk signaling and is crucial for TCR-mediated T cell activation. PMID: 23359496
11. Kidins220/ARMS is a functional mediator of multiple receptor signalling pathways. PMID: 22562556
12. a novel partner of Kidins220/ARMS PMID: 22609016
13. induction of morphological polarization in primary T lymphocytes and Jurkat cells enhances Kidins220/ARMS colocalization with ICAM-3 PMID: 21381019
14. Ankyrin repeat-rich membrane spanning expression, conjunctly with tumour thickness or ulceration, may serve as a prognostic factor in patients with cutaneous melanoma. PMID: 21343931
15. endogenous PKD1, PKD2, and Kidins220 co-exist with neurotensin-containing vesicles PMID: 18048355
16. Down-regulation of ARMS results in inhibition of anchorage-independent growth in soft agar and restrictive growth of melanoma in severe combined immunodeficient mice PMID: 18089783
17. Ankyrin-rich membrane spanning protein is a major factor that links neurotrophin signaling to nuclear factor-kappa B. PMID: 18501627
18. sigma-1R overexpression drives sigma agonist-independent dissociation of ANK 220 from IP3R-3, resulting in activation PMID: 18539593

Show More

Hide All

HGNC: 29508

OMIM: 615759

KEGG: hsa:57498

STRING: 9606.ENSP00000256707

UniGene: Hs.467627