KIDINS220

KIDINS220, also known as Kinase D-interacting substrate of 220 kDa, is a transmembrane protein. It is also commonly referred to as ARMS (ankyrin repeat-rich membrane spanning). This protein plays a crucial role in signal transduction. It participates in the MAPK and PI3K - AKT signaling pathways, which are involved in cell survival, differentiation, and proliferation.
Mutations or abnormal expression of KIDINS220 have been linked to various diseases, such as certain types of cancers and neurodegenerative disorders. In drug development, KIDINS220 is being explored as a potential therapeutic target. Some pre - clinical studies are underway to develop compounds that can modulate its function to treat related diseases.