KIF13A Antibody, HRP conjugated

Datasheet
Code CSB-PA880944LB01HU
Size US$299
Uniprot No. Q9H1H9
Immunogen Recombinant Human Kinesin-like protein KIF13A protein (1383-1537AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Kinesin-like protein KIF13A (Kinesin-like protein RBKIN), KIF13A, RBKIN
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names KIF13A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Midbody, Endosome membrane, Golgi apparatus membrane
Protein Families TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Tissue Specificity Widely expressed, with highest levels in heart, brain and skeletal muscle.
Database Links

HGNC: 14566

OMIM: 605433

KEGG: hsa:63971

STRING: 9606.ENSP00000259711

UniGene: Hs.94499

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