KIF13A Antibody

Code CSB-PA880944LA01HU
Size US$166
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Image
  • IHC image of CSB-PA880944LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA880944LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KIF13A Polyclonal antibody
Uniprot No.
Target Names
KIF13A
Alternative Names
bA500C11.2 antibody; FLJ27232 antibody; Homolog of mouse KIF13A mannose 6 phosphate receptor transporter antibody; KI13A_HUMAN antibody; KIF 13A antibody; Kif13a antibody; Kinesin family member 13A antibody; Kinesin like protein KIF13A antibody; Kinesin like protein RBKIN antibody; Kinesin-like protein KIF13A antibody; Kinesin-like protein RBKIN antibody; RBKIN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Kinesin-like protein KIF13A protein (1383-1537AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The KIF13A Antibody (Product code: CSB-PA880944LA01HU) is Non-conjugated. For KIF13A Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA880944LB01HU KIF13A Antibody, HRP conjugated ELISA
FITC CSB-PA880944LC01HU KIF13A Antibody, FITC conjugated
Biotin CSB-PA880944LD01HU KIF13A Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.
Gene References into Functions
  1. the crystal structure of a catalytically active kinesin-13 monomer (Kif2A) in complex with two bent alphabeta-tubulin heterodimers in a head-to-tail array, providing a view of these interactions, is reported. PMID: 29980677
  2. that KIF13A plays an important role in the transport of influenza A viral ribonucleoproteins PMID: 29061883
  3. KIF13A interacts and cooperates with RAB11 to generate endosomal tubules. PMID: 24462287
  4. kjh kiiou ouiy 8yt 8iy 7i9y PMID: 24859087
  5. the kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization PMID: 21873978
  6. Functionally characterizes the homologous mouse protein. PMID: 11106728
  7. PtdIns(3)P production is essential for proper cytokinesis. PtdIns(3)P-binding centrosomal protein FYVE-CENT and TTC19 control cytokinesis through their translocation from the centrosome to the midbody mediated by the kinesin protein KIF13A. PMID: 20208530
  8. show that the clathrin adaptor AP-1 and the kinesin motor KIF13A together create peripheral recycling endosomal subdomains in melanocytes required for cargo delivery to maturing melanosomes. PMID: 19841138

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Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane. Note=Recruited to the midbody during cytokinesis.
Protein Families
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Tissue Specificity
Widely expressed, with highest levels in heart, brain and skeletal muscle.
Database Links

HGNC: 14566

OMIM: 605433

KEGG: hsa:63971

STRING: 9606.ENSP00000259711

UniGene: Hs.94499

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