KIRREL2 Antibody

Datasheet

Code	CSB-PA995714
Size	US$166
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Image	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human testis tissue, Jurkat cells, mouse liver tissue, Primary antibody: CSB-PA995714(KIRREL2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

Q6UWL6

Target Names

KIRREL2

Alternative Names

FILTRIN antibody; Kin of IRRE like 2 (Drosophila) antibody; Kin of IRRE-like protein 2 antibody; Kin of irregular chiasm like 2 antibody; Kin of irregular chiasm-like protein 2 antibody; KIRR2_HUMAN antibody; KIRREL2 antibody; NEPH3 antibody; Nephrin like 3 antibody; nephrin-like gene 1 antibody; Nephrin-like protein 3 antibody; NLG1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human KIRREL2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May regulate basal insulin secretion.

Gene References into Functions

SNP V353M confers high risk of renal failure in primary hematuric glomerulopathies and predisposition to microalbuminuria in the general population PMID: 28334007
summarize the current knowledge of the functions of nephrin and Neph-family proteins and transcription factors and agents that control nephrin and Neph3 gene expression. PMID: 24219158
Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-kappaB and silenced by DNA methylation. PMID: 21980157
Identification of Filtrin as a member of nephrin-like proteins. PMID: 12504092
KIRREL2 protein is a beta-cell-expressed Ig domain protein and may be involved in pancreas development or beta cell function PMID: 12837264
Filtrin can act as autoantigen, and autoantibodies against these can be detected in patients with type 1 diabetes. PMID: 16741999
NF-kappaB and Sp1 response elements are essential for the basal transcriptional activity of the Neph3 promoter. PMID: 19703278
Filtrin is a novel protein with substantial homology to nephrin. It is a transmembrane protein of the immunoglobulin superfamily (apparent molecular weight 107 kDa) and most prominently expressed in the pancreas, lymph nodes as well as kidney glomerulus. PMID: 12504092

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Immunoglobulin superfamily

Tissue Specificity

Highly expressed in beta-cells of the pancreatic islets.

Database Links

HGNC: 18816

OMIM: 607762

KEGG: hsa:84063

STRING: 9606.ENSP00000353331

UniGene: Hs.145729

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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