KLF7 Antibody

Code CSB-PA070100
Size US$100
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Product Details

Uniprot No.
Target Names
KLF7
Alternative Names
KLF7 antibody; KLF7_HUMAN antibody; Krueppel like factor 7 antibody; Krueppel-like factor 7 antibody; Kruppel like factor 7 antibody; Ubiquitous krueppel like factor antibody; Ubiquitous krueppel-like factor antibody; UKLF antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human KLF7.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional factor. Plays a critical role in neuronal morphogenesis and survival of sensory neurons. Represses the corneal epithelium differentiation. Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin.
Gene References into Functions
  1. Kruppel family member KLF7 promotes the corneal progenitor cell state; on many genes, KLF7 antagonized the corneal differentiation-promoting KLF4. PMID: 28916725
  2. KLF7 has an important role in gastric cancer (GC) progression, as it inhibits GC cell migration and may serve as a prognostic marker PMID: 28977783
  3. Higher expression of TLR4 and KLF7 may play a vital role in the process of inflammation induced by obesity in visceral adipose tissue PMID: 27714571
  4. a dominant mutation in FBXO38 causes adult-onset, progressive spinal muscular atrophy with calf predominance PMID: 24207122
  5. KLF7 was upregulated by morphine at both the transcriptional and the translational levels, promoting cell growth up to day 4 PMID: 14644156
  6. The gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes. PMID: 15937668
  7. KLF7 may contribute to the pathogenesis of type 2 diabetes through an impairment of insulin biosynthesis and secretion in pancreatic beta-cells and a reduction of insulin sensitivity in peripheral tissues. PMID: 16339272
  8. We identified a novel association between the minor A-allele of KLF7 and protection against obesity in the Danish population PMID: 19147600

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Subcellular Location
Nucleus.
Protein Families
Krueppel C2H2-type zinc-finger protein family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 6350

OMIM: 604865

KEGG: hsa:8609

STRING: 9606.ENSP00000309570

UniGene: Hs.471221

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