KPNA6 Antibody

Datasheet

Code	CSB-PA012488ESR1HU
Size	US$166
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Image	Western blot All lanes: KPNA6 antibody at 4.25μg/ml Lane 1: PC-3 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: U251 whole cell lysate Lane 4: 293T whole cell lysate Lane 5: Mouse brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 60 kDa Observed band size: 60 kDa Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA012488ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA012488ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KPNA6 Polyclonal antibody

Uniprot No.

O60684

Target Names

KPNA6

Alternative Names

FLJ11249 antibody; IMA7_HUMAN antibody; Importin alpha 7 subunit antibody; Importin alpha S2 antibody; Importin subunit alpha 7 antibody; Importin subunit alpha-7 antibody; IPOA 7 antibody; IPOA7 antibody; Karyopherin alpha 6 antibody; Karyopherin alpha 6 (importin alpha 7) antibody; Karyopherin subunit alpha 6 antibody; Karyopherin subunit alpha-6 antibody; KPNA 6 antibody; KPNA 7 antibody; Kpna6 antibody; KPNA7 antibody; MGC17918 antibody; OTTHUMP00000004532 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Importin subunit alpha-7 protein (277-536AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene References into Functions

Development of a pipeline for automated, high-throughput analysis of PSPC1 paraspeckle protein isoforms reveals specific roles for KPNA2, KPNA4 and KPNA6 proteins. PMID: 28240251
the data showed that viral infection induced an elevation of the KPNA6 protein level due to an extension of the KPNA6 half-life via viral interference of the ubiquitin-proteasomal degradation of KPNA6. Notably, KPNA6 silencing or knockout dramatically reduced the replication of PRRSV and ZIKV. PMID: 29444946
a decreased H7N9 influenza A virus polymerase activity when importin-alpha7 was silenced by siRNA, is reported. PMID: 28189564
Bel1 fragment with residues 215-223, which bears the NLS, interacts with KPNA1, KPNA6, and KPNA7. PMID: 25272585
Importin alpha1 and alpha7 are positive regulators of human-like polymerase activity and pathogenicity beyond their role in nuclear transport. PMID: 22275867
Overexpression of KPNA6 facilitates KEAP1 nuclear import and attenuates NRF2 signaling, whereas knockdown of KPNA6 slows down KEAP1 nuclear import and enhances the NRF2-mediated adaptive response induced by oxidative stress. PMID: 21383067
Importin alpha5 and alpha7 bind to Stat3 upon cytokine stimulation. PMID: 16298512

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Protein Families

Importin alpha family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 6399

OMIM: 610563

KEGG: hsa:23633

STRING: 9606.ENSP00000362728

UniGene: Hs.470588

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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