L2 Antibody, HRP conjugated

Code CSB-PA356939LB01HMN
Size US$166
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Product Details

Full Product Name
Rabbit anti-Human papillomavirus type 18 L2 Polyclonal antibody
Uniprot No.
Target Names
L2
Alternative Names
L2 antibody; Minor capsid protein L2 antibody
Raised in
Rabbit
Species Reactivity
Human papillomavirus type 18
Immunogen
Recombinant Human papillomavirus type 18 Minor capsid protein L2 protein (1-462AA)
Immunogen Species
Human papillomavirus type 18
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
Subcellular Location
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein Families
Papillomaviridae L2 protein family
Database Links

KEGG: vg:1489091

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