LAMC3 Antibody

Code CSB-PA012737GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
LAMC3
Alternative Names
LAMA 1 antibody; LAMA antibody; LAMA1 antibody; LAMB1 antibody; Lamc3 antibody; LAMC3_HUMAN antibody; Laminin A chain antibody; Laminin alpha 1 antibody; Laminin alpha 1 chain antibody; Laminin B1 chain antibody; Laminin subunit beta 1 antibody; Laminin subunit gamma-3 antibody; Laminin-12 subunit gamma antibody; Laminin-14 subunit gamma antibody; Laminin-15 subunit gamma antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human LAMC3-Specific
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Gene References into Functions
  1. LAMC3 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
  2. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
  3. These data suggest that beta2 and gamma3-containing laminins play an important dose-dependent role in development of the cortical pial basement membrane PMID: 22961762
  4. Recessive LAMC3 mutations cause malformations of occipital cortical development. PMID: 21572413
  5. Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains PMID: 18697739

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Involvement in disease
Cortical malformations occipital (OCCM)
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue Specificity
Broadly expressed in: skin, heart, lung, and the reproductive tracts.
Database Links

HGNC: 6494

OMIM: 604349

KEGG: hsa:10319

STRING: 9606.ENSP00000354360

UniGene: Hs.201805

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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