LAMC3 Antibody

Datasheet

Code	CSB-PA914944
Size	US$297
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Image	Western blot analysis of extracts from K562 cells and 3T3 cells, using LAMC3 antiobdy. Immunohistochemistry analysis of paraffin-embedded human brain tissue using LAMC3 antibody. Immunofluorescence analysis of LOVO cells, using LAMC3 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LAMC3 Polyclonal antibody

Uniprot No.

Q9Y6N6

Target Names

LAMC3

Alternative Names

LAMA 1 antibody; LAMA antibody; LAMA1 antibody; LAMB1 antibody; Lamc3 antibody; LAMC3_HUMAN antibody; Laminin A chain antibody; Laminin alpha 1 antibody; Laminin alpha 1 chain antibody; Laminin B1 chain antibody; Laminin subunit beta 1 antibody; Laminin subunit gamma-3 antibody; Laminin-12 subunit gamma antibody; Laminin-14 subunit gamma antibody; Laminin-15 subunit gamma antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from internal of Human LAMC3.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IHC,IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100
IF	1:100-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Gene References into Functions

LAMC3 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
These data suggest that beta2 and gamma3-containing laminins play an important dose-dependent role in development of the cortical pial basement membrane PMID: 22961762
Recessive LAMC3 mutations cause malformations of occipital cortical development. PMID: 21572413
Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains PMID: 18697739

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Involvement in disease

Cortical malformations occipital (OCCM)

Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane.

Tissue Specificity

Broadly expressed in: skin, heart, lung, and the reproductive tracts.

Database Links

HGNC: 6494

OMIM: 604349

KEGG: hsa:10319

STRING: 9606.ENSP00000354360

UniGene: Hs.201805

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

PI3K-Akt signaling pathway Focal adhesion

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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