LAMTOR1 Antibody, HRP conjugated

Code CSB-PA757083LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LAMTOR1 Polyclonal antibody
Uniprot No.
Target Names
LAMTOR1
Alternative Names
C11orf59 antibody; LAMTOR1 antibody; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 antibody; Lipid raft adaptor protein p18 antibody; LTOR1_HUMAN antibody; p18 antibody; p27Kip1-releasing factor from RhoA antibody; p27RF-Rho antibody; PDRO antibody; PP7157 antibody; Protein associated with DRMs and endosomes antibody; Ragulator complex protein LAMTOR1 antibody; ragulator complex protein PDRO antibody; Ragulator1 antibody; RhoA activator C11orf59 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ragulator complex protein LAMTOR1 protein (2-161AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
Gene References into Functions
  1. In vitro reconstitution and experiments with site-directed mutagenesis defined the physiological importance of LAMTOR1 in assembling the remaining components to ensure fidelity of mTORC1 signaling. PMID: 28935770
  2. LAMTOR1 is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning. PMID: 28993467
  3. Study found that NF1 negatively regulates mTOR signaling in a LAMTOR1-dependent manner. In addition, the cell growth and survival of NF1-deficient cells have become dependent on hyperactivation of the mTOR pathway, and the tumorigenic properties of these cells have become dependent on LAMTOR1. PMID: 28174230
  4. Western blot experiments designed to detect flotillin 2, TMEM256, Rab3B and LAMTOR1 showed that the level of these proteins was higher in urinary exosomes from prostate cancer patients compared to healthy males PMID: 27664330
  5. Data suggest that ablation of p18/LAMTOR1 suppresses starvation-induced cell death by stimulating autophagy through modulation of p27(kip1) activity. PMID: 26032166
  6. LAMTOR1 expression affects the tuning of lysosomal activation that can lead to p53-dependent apoptosis through excessive catabolism. PMID: 22513874
  7. A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC. PMID: 21087931
  8. MT1-MMP-associated protein p27RF-Rho binds p27(kip1) and prevents p27(kip1) from binding to RhoA. [p27RF-Rho] PMID: 19654316
  9. A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation PMID: 20381137
  10. Studies in rat and mice, identified the rat p18 protein as an endosomal membrane anchoring protein which interacts with MEK1 scaffold p14/MP1 and mobilizes them to late endosome. PMID: 19177150

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Subcellular Location
Late endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane.
Protein Families
LAMTOR1 family
Database Links

HGNC: 26068

OMIM: 613510

KEGG: hsa:55004

STRING: 9606.ENSP00000278671

UniGene: Hs.731528

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