LCP1 Antibody, HRP conjugated

Datasheet
Code CSB-PA012824YB01HU
Size US$299
Uniprot No. P13796
Protocols ELISA Protocol
Immunogen Recombinant Human Plastin-2 protein (2-627AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1), LCP1, PLS2
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names LCP1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Actin-binding protein
Involvement in disease Chromosomal aberrations involving LCP1 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;13)(q27;q14), with BCL6.
Subcellular Location Cytoplasm, cytoskeleton, Cell junction, Cell projection, Cell projection, ruffle membrane, Peripheral membrane protein, Cytoplasmic side
Tissue Specificity Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
Database Links

HGNC: 6528

OMIM: 153430

KEGG: hsa:3936

STRING: 9606.ENSP00000315757

UniGene: Hs.381099

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