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LIME1 Antibody, Biotin conjugated

Datasheet
Code CSB-PA884463LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LIME1 Polyclonal antibody
Uniprot No.
Q9H400
Target Names
LIME1
Alternative Names
LIME1 antibody; LIME antibody; LP8067 antibody; Lck-interacting transmembrane adapter 1 antibody; Lck-interacting membrane protein antibody; Lck-interacting molecule antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Lck-interacting transmembrane adapter 1 protein (170-295AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Gene References into Functions
  1. these results establish LIME as a transmembrane adaptor protein linking TCR stimulation to IS formation and integrin activation through activation of Vav(Vav guanine nucleotide exchange factor) PMID: 22395814
Subcellular Location
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
Tissue Specificity
Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level).
Database Links

HGNC: 26016

OMIM: 609809

KEGG: hsa:54923

STRING: 9606.ENSP00000309521

UniGene: Hs.233220

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