LLGL2 Antibody, FITC conjugated

1. The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex formation. PMID: 24513855
2. It is correlated with lymphatic invasion and lymph node metastasis. PMID: 24318287
3. Loss or aberrant Lgl2 staining was useful in identifying Barrett gastric foveolar dysplasia PMID: 23332925
4. Hugl-2 induces MET and suppresses Snail tumorigenesis. PMID: 22580609
5. Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control. PMID: 23110097
6. There is a role of Lgl2 immunohistochemistry as an adjunct in the diagnosis of foveolar-type gastric dysplasia. PMID: 20941506
7. Lgl2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias. PMID: 20233622
8. binding between Lgl2 and LGN play a role in mitotic spindle organization through regulating formation of the LGN.NuMA complex; Lgl2 forms a Lgl2.Par-6.aPKC.LGN complex, which responds to mitotic signaling to establish normal cell division PMID: 15632202
9. The identification and functional characterization of the promoter region ( approximately 1.2kb) of the Hugl-2 gene are reported. PMID: 18155665
10. Retention of Lgl2 expression is critical for the epithelial phenotype;its loss might be involved in metastasis. PMID: 18199550
11. We propose that Lgl2 may be a potential marker to rule out gastric epithelial dysplasia and adenocarcinoma in diagnostic specimens. PMID: 19407852

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HGNC: 6629

KEGG: hsa:3993

STRING: 9606.ENSP00000376333

UniGene: Hs.514477