LPAR5 Antibody

Datasheet

Code	CSB-PA013051OA01HU
Size	US$166
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Image	IHC image of CSB-PA013051OA01HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of Hela cells with CSB-PA013051OA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LPAR5 Polyclonal antibody

Uniprot No.

Q9H1C0

Target Names

LPAR5

Alternative Names

LPAR5; GPR92; GPR93; Lysophosphatidic acid receptor 5; LPA receptor 5; LPA-5; G-protein coupled receptor 92; G-protein coupled receptor 93

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Peptide sequence from Human Lysophosphatidic acid receptor 5 protein (310-326AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LPAR5 Antibody (Product code: CSB-PA013051OA01HU) is Non-conjugated. For LPAR5 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA013051OB01HU	LPAR5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013051OC01HU	LPAR5 Antibody, FITC conjugated
Biotin	CSB-PA013051OD01HU	LPAR5 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Gene References into Functions

It signaling may play a key role in the mechanisms underlying neuropathic pain following demyelination in the brain. PMID: 29409686
These results suggest that the cell motile activity is regulated through the induction of LPA5 by phorbol ester and anticancer drug treatments in A375cells. PMID: 29309788
These results suggest that the diverse roles of LPA4, LPA5 and LPA6 are involved in the activation of tumor progression in pancreatic cancer cells. PMID: 25849892
Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma. PMID: 25294670
MMP-2 and MMP-9 were found in HT1080L5 cells, in comparison with control cells. These results suggest that LPA signaling via LPA5 negatively regulates the cell motile and invasive activities of human sarcoma cells. PMID: 24676544
These results suggest that LPA5 may act as a negative regulator of cellular responses in mouse fibroblast 3T3 cells, similar to the case for LPA1. PMID: 24632199
It was shown that lysophosphatidic acid 5 receptor transactivated the epidermal growth factor receptor and that inhibition of epidermal growth factor receptor blocked lysophosphatidic acid 5 receptor-dependent activation of NHE3. PMID: 21832242
LPA5 is a bona fide LPA receptor on human mast cells responsible for the majority of LPA induced MIP-1beta release. PMID: 21464938
LPA4 and LPA5 receptors induce osteoblastic differentiation of human mesenchymal stem cells PMID: 20069565
Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients. PMID: 19860625
GPR92 is proposed as a fifth LPA receptor, LPA5, which likely has distinct physiological functions in view of its expression pattern. PMID: 16774927
FPP and NAG play a role in the sensory nervous system through activation of GPR92 PMID: 18499677
Four residues involved in ligand recognition in LPA(5) were identified as follows: R2.60N mutant abolished receptor activation, whereas H4.64E, R6.62A, and R7.32A greatly reduced receptor activation. PMID: 19366702

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.

Database Links

HGNC: 13307

OMIM: 606926

KEGG: hsa:57121

STRING: 9606.ENSP00000327875

UniGene: Hs.155538

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

PI3K-Akt signaling pathway Oxidative Phosphorylation Phospholipase D signaling pathway Rap1 signaling pathway Melanogenesis G protein coupled receptor signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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