LPP Antibody

Code CSB-PA856611LA01HU
Size US$166
Order now
Image
  • Western Blot
    Positive WB detected in: 293T whole cell lysate
    All lanes: LPP antibody at 7.5μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 66 kDa
    Observed band size: 66 kDa

  • IHC image of CSB-PA856611LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA856611LA01HU diluted at 1:300 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LPP Polyclonal antibody
Uniprot No.
Target Names
LPP
Alternative Names
DKFZp779O0231 antibody; FLJ30652 antibody; FLJ41512 antibody; LIM domain containing preferred translocation partner in lipoma antibody; LIM domain-containing preferred translocation partner in lipoma antibody; LIM protein antibody; Lipoma preferred partner antibody; Lipoma-preferred partner antibody; lpp antibody; LPP_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Lipoma-preferred partner protein (227-391AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The LPP Antibody (Product code: CSB-PA856611LA01HU) is Non-conjugated. For LPP Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA856611LB01HU LPP Antibody, HRP conjugated ELISA
FITC CSB-PA856611LC01HU LPP Antibody, FITC conjugated
Biotin CSB-PA856611LD01HU LPP Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:100-1:300
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
Gene References into Functions
  1. Data indicate a function for lipoma preferred partner (LPP) in the formation of invadopodia and a requirement for LPP in mediating the metastatic ability of breast cancer cells. PMID: 28436416
  2. This is the first report of epigenetic regulation of the intronic miR-28-5p expression by promoter DNA methylation of its host gene, LPP. PMID: 28775176
  3. meta-analysis provides robust estimates that polymorphisms in LPP and TAGAP genes are potential risk factors for celiac disease in Europeans and Americans PMID: 28208589
  4. this study shows the importance of PP2A complexes with the LIM domains of lipoma-preferred partner in cell adhesion and migration dynamics PMID: 26945059
  5. alteration of LPP expression markedly changes the collectiveness and metastatic potential of cancer cells PMID: 26028032
  6. Results suggest that rs4686484 is the functional variant in this locus, while LPP expression is decreased in CeD. PMID: 24334606
  7. 3q28 rs6444305 in LPP gene is associated with follicular lymphoma. PMID: 25279986
  8. interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells. PMID: 23447672
  9. Three polymorphisms of LPP gene were selected and replicated in additional 1132 PCOS cases and 1142 controls. Our results suggest that LPP gene might be a novel candidate for PCOS PMID: 23056290
  10. The results suggest that genomic alterations and clearly deleterious sequence changes in the LPP gene are not a common cause of esophageal atresia/tracheoesophageal fistula or VACTERL association. PMID: 22639458
  11. LPP is a nucleocytoplasmatic shuttle protein linking focal adhesion dynamics to the transcriptional machinery. PMID: 19701494
  12. Gene expression levels of bcl-6, lpp and miR-28 are different in various diffuse large B cell lymphoma cell lines. PMID: 19236753
  13. haploinsufficiency of LPP may be a novel cause of conotruncal cardiac anomalies, particularly forms of tetralogy of Fallot PMID: 20949626
  14. LPP contains specific domains that enable its focal adhesion and nuclear targeting capacity PMID: 12441356
  15. Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas. PMID: 12505264
  16. LPP and Scrib proteins localize in cell-cell contacts. This interaction links Scrib to a communication pathway between cell-cell contacts and the nucleus, and implicates LPP in Scrib-associated functions PMID: 15649318
  17. Translocation in chromosome 3 and 12 involves fusion of this protein with HMGA2 in pulmonary chondroid hamartoma. PMID: 16271958
  18. HMGA2-LPP fusion promotes chondrogenesis by upregulating cartilage-specific collagen gene expression through the N-terminal DNA binding domains. PMID: 16375854
  19. LPP appears to be a vascular smooth muscle (SMSC) differentiation marker that plays a role in regulating SMC migration. PMID: 16397143
  20. LPP can shuttle between the cytoplasm and the nucleus, suggesting they may transfer information directly from the cytoskeleton or focal adhesions to the transcription machinery. PMID: 16484626
  21. By manipulating LPP levels, we show that it acts to upregulate the transactivation capacity of PEA3. PMID: 16738319
  22. The function of LPP and palladin is context dependent, that they play a critical role in cytoskeletal remodeling, respond to signals induced by vascular injury as well as signals that induce smooth muscle cell hypertrophy, such as angiotension II. PMID: 17322171
  23. expression of LPP and palladin are modulated by a mix of mechanical cues, oxidative stress and substrate composition which translate into their up or down regulation in vessel wall injury and early atherogenesis. PMID: 19205907

Show More

Hide All

Involvement in disease
A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.; DISEASE: Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.; DISEASE: Note=A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.; DISEASE: Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia.
Subcellular Location
Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.
Protein Families
Zyxin/ajuba family
Tissue Specificity
Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.
Database Links

HGNC: 6679

OMIM: 600700

KEGG: hsa:4026

STRING: 9606.ENSP00000318089

UniGene: Hs.720220

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*